Results 111 to 120 of about 16,204,826 (289)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Rapid and reversible humidity-dependent colour change by water film formation in a scaled springtail. [PDF]

open access: yesJ R Soc Interface, 2023
Vanthournout B   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

The Effects of Activated Carbon Toothpastes on Orthodontic Elastomeric Chains—An In Vitro Study

open access: yesApplied Sciences
Objectives: Using toothpaste with activated carbon might increase the decay of orthodontic elastomeric chains’ (ECs) tensile strength, thereby compromising orthodontic treatment. Therefore, this study aimed to evaluate the influence of activated charcoal
Pedro Mariano Pereira   +3 more
doaj   +1 more source

Altitude, latitude and climate zone as determinants of mountain hare (Lepus timidus) coat colour change. [PDF]

open access: yesEcol Evol, 2023
Stokes AW   +5 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Farklı Diş Beyazlatma Yöntemlerinin Dişlerde Renk Değişimi ve Yüzey Özelliklerine Etkileri

open access: yesActa Odontologica Turcica
Amaç: Işık ile aktive edilmeden, LED ışık kaynağı ile ve Er: YAG lazer ile aktive edilen %40 konsantrasyondaki hidrojen peroksit (HP) beyazlatma jeli ile beyazlatma işleminin renk değişikliğine, yüzeyin mikrosertlik ve pürüzlülük özelliklerine olan ...
Işıl Turp   +3 more
doaj   +1 more source

Colour Changes in Crustacea [PDF]

open access: yesNature, 1932
COLOUR changes, in response to light and darkness and to background tint, are well known in prawns and shrimps. I have found this faculty to be present in other decapod Crustacea. It is exhibited by Porcellana longicomis, Eupagurus berrihardus, young Galathea strigosa and G. dispersa, and in two cases referred to below.
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

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