Results 81 to 90 of about 4,745,065 (295)

Analysis of the behavior of reinforced concrete columns strengthened with sleeve wedge bolts and a self compacting concrete layer

open access: yesRevista IBRACON de Estruturas e Materiais
Strengthening of reinforced concrete columns by jacketing is one of the most common structural rehabilitation techniques in Brazil. For adequate performance, it is necessary, among others, to avoid detachment of the new concrete layer (strengthening ...
M. G. Marques   +3 more
doaj   +1 more source

The motion of a plate in a rotating fluid at an arbitrary angle of attack [PDF]

open access: yes, 1972
Slow motion of a thin plate at a finite angle of attack in a rotating container filled with a viscous incompressible fluid is analysed. The Rossby and Ekman numbers are assumed to be small.
Wilcox, David C.
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Methods of analysis of a reinforced concrete section under bending with axial force in the post-yield range

open access: yesBudownictwo i Architektura, 2014
Predicting the behaviour of plastic hinges subjected to large inelastic deformations caused by extreme loads such as earthquakes plays an important role in assessing maximum stable deformation capacities of framed concrete structures. This paper presents
Jacek Korentz
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

PUNCHING CALCULATION OF REINFORCED CONCRETE FLOOR SLABS

open access: yesВестник Дагестанского государственного технического университета: Технические науки, 2016
. In this paper is considered the modeling of a monolithic reinforced concrete buildings structures by the spatial plate-core scheme and study of the floor slabs punching problem. When creating the finite element model of the building structure the floor
E. K. Agakhanov   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

On the record of vertebral deformities in Mastacembelus mastacembelus collected from the lower reaches of Euphrates River, Iraq

open access: yesBoletim do Instituto de Pesca, 2016
Severe deformity such as coalescence of vertebrae, compact vertebrae, loss of vertebral parts, and different levels of deformed vertebral centra and minor deformities such as undulation of the haemal spines of the vertebrae are reported in six specimens
Laith JAWAD   +2 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

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