Results 51 to 60 of about 1,934 (272)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Ironia, sarcasme i altres recursos en l’expressió periodística de Joan Fuster. El cas de les Notes d’un desficiós (1979-1984) / Irony, sarcasm and other resources in the journalistic works of Joan Fuster. The case of the Notes d’un desficiós (1979-1984)

Cultura, Lenguaje y Representación, 2018
L’expressió irònica és un dels trets discursius de l’assagista i columnista Joan Fuster i Ortells (1922-1992). Aquest registre, que empra mitjançant diferents procediments, està també present en la seua producció periodística, un conjunt discursiu gens ...
Nel·lo Pellisser
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

THE VERTEBRATE FAUNA OF THE LOWER PLIOCENE CONTINENTAL DEPOSITS IN THE EBRO DELTA (BAIX EBRE BASIN, NE SPAIN)

Rivista Italiana di Paleontologia e Stratigrafia
The Pliocene faunas of the northeastern Iberian Peninsula are poorly known due to the scarcity of deposits from this interval. In this context, the site of Sant Nofre-Campredó (Baix Ebre, Catalonia, Spain), comprising two contemporaneous outcrops ...
Pedro Piñero, JORDI AGUSTÍ, HUGUES-ALEXANDRE BLAIN, DAVID M. ALBA, MARC FURIÓ, CHIARA ANGELONE, ADRIANA LINARES-MARTÍN, RAFAEL MARQUINA-BLASCO, CASTO LABORDA-LÓPEZ, ALVARO ARASA-TULIESA, ISAAC CASANOVAS-VILAR   +10 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Developing countries can adapt to climate change effectively using nature-based solutions

Communications Earth & Environment
Evidence on the effectiveness of climate change adaptation interventions in low- and middle-income countries has been rapidly growing in recent years, particularly in the agricultural and coastal sectors.
Sergio Villamayor-Tomas, Alexander Bisaro, Kevin Moull, Amaia Albizua, Isabel Mank, Jochen Hinkel, Gerald Leppert, Martin Noltze   +7 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Les quatre columnes [reportatge fotogràfic]

, 2016
Les columnes originals col·locades el 1919, de l'arquitecte Josep Puig i Cadafalch, foren enderrocades el 1928. Les columnes reconstruïdes entre 2007-2010 estan ubicades a prop de la ubicació anterior, sobre les fonts de Montjuïc.
Sales Encinas, Ramón
core  

La construcció dels espais de la bibliofília en l’articulisme de Joan Francesc Mira

Cultura, Lenguaje y Representación, 2017
Resum: La biblioteca ha estat un àmbit que ha fascinat l’ésser humà a causa dels diferents nivells interpretatius que aquest espai genera. Aquest treball revisa els assajos periodístics en què l’escriptor Joan Francesc Mira s’hi refereix a fi d’il ...
Sergi Serra Adsuara
doaj