Results 81 to 90 of about 835,149 (319)

Agronomic and organizational aspects of Barcelona’s community gardens

Frontiers in Sustainable Food Systems
As food security becomes a growing concern in urban areas worldwide, municipal authorities are actively seeking ways to enhance and complement the food systems of their respective cities.
Diego Maximiliano Macall, Xavier Gabarrell Durany, Xavier Gabarrell Durany, Sergio Villamayor-Tomas   +3 more
doaj   +1 more source

La història medieval i les noves tècniques d'anàlisi per ordinador: els testaments de Vic del segle XIII [PDF]

, 2015
En els darrers anys, les aplicacions de la informàtica han arribat a gairebé tots els camps de i'activitat humana. En els estudis històrics, però, aquesta aplicació ha quedat relegada quasi exclusivament a treballs d'història moderna i contemporània, on ...
Ollich i Castanyer, Imma, 1951-
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

A Review on the Latest Early Pleistocene Carnivoran Guild from the Vallparadís Section (NE Iberia)

Quaternary
The Vallparadís Section encompasses various geological layers that span a significant chronological range, extending from the latest Early Pleistocene to the early Middle Pleistocene, covering a timeframe from approximately 1.2 to 0.6 Ma.
Joan Madurell-Malapeira, Maria Prat-Vericat, Saverio Bartolini-Lucenti, Andrea Faggi, Darío Fidalgo, Adrian Marciszak, Lorenzo Rook   +6 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Biomarkers and metal content in white seabream (Diplodus sargus) and its relationship with the occurrence of the Abnormal Tough Syndrome

Environmental Pollution and Management
There is still controversy on the cause of the incidence of abnormal tough syndrome (ATS) in some fish species, mainly the white seabream (Diplodus sargus). This work analyses the incidence of the ATS in white seabream in areas with a different extent of
Montserrat Solé, Sergi Omedes, Conxi Rodríguez-Prieto, María Lorenzo, Margarida Casadevall   +4 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Time in and for nature-based solutions. No quick fix solutions for complex ecological and social processes

Nature-Based Solutions
Nature-based solutions (NbS) are an increasingly widespread tool in environment and development policies. They embody the idea that nature and natural processes can be purposefully used by humans to provide solutions to pressing environmental and social ...
Ina Lehmann, Julia Grosinger, Steffen Bauer, Jean Carlo Rodríguez de Francisco, Katarzyna Negacz, Jonas Hein   +5 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source