Results 231 to 240 of about 11,656,079 (296)

Dual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphoma. [PDF]

Cell Death Dis
Wang W, Zhou H, Tan S, Qin D, Wang S, Xu C, Lei X, Li W, Wang L, Fu S, Jia S, Xu B, Zha J.   +12 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Synergistic Anticancer Activity of Cannabinoids and Terpenes Against Triple-Negative Breast Cancer Resistance. [PDF]

Int J Mol Sci
Aare M, Lazarte JM, Nathani A, Boirie B, Turley TN, Copland JA, Singh M.   +6 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

When Selectivity Increases Uncertainty: Context-Dependent Pharmacology in Antibody Drug Development. [PDF]

Clin Transl Sci
Liao X, Cao Y.
europepmc   +1 more source

A new therapeutic strategy for spotted fever group rickettsioses: a proposal for evaluating combination therapy with tetracycline and fluoroquinolones. [PDF]

Front Cell Infect Microbiol
Itoh K, Tsutani H, Mitsuke Y, Ikawa M, Iwasaki H.   +4 more
europepmc   +1 more source

Fosfomycin combination therapy in high-risk paediatric patients with multidrug-resistant infections: a retrospective study. [PDF]

Eur J Pediatr
Denina M, Badiali L, Vitale R, Robasto F, Funiciello E, Silvestro E, Pruccoli G, Garazzino S.   +7 more
europepmc   +1 more source

Evaluation of the Synergistic Activity of Anidulafungin with Isavuconazole, Voriconazole, Posaconazole, and Amphotericin B in <i>Candida auris</i> (<i>Candidozyma auris</i>) Isolates. [PDF]

Infect Drug Resist
Turan D, Sarmis A, Adaleti R, Aksaray S.
europepmc   +1 more source

Perillaldehyde combined with domiphen: synergistic bactericidal and anti-biofilm activity against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. [PDF]

Front Cell Infect Microbiol
Qiao J, Wu S, Fu C, Zhao Q, Gong Y, Xu L, Tang D, Gao Y, Luo W.   +8 more
europepmc   +1 more source