Results 131 to 140 of about 28,100,614 (312)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Combination ledipasvir-sofosbuvir for the treatment of chronic hepatitis C virus infection: a review and clinical perspective

, 2016
Marcel Nkuize,1 Thomas Sersté,1,2 Michel Buset,1 Jean-Pierre Mulkay11Department of Gastroenterology and Hepatology, Saint-Pierre University Hospital, 2Department of Gastroenterology, Pancreatology and Hepatology, Hôpital Academique Erasme ...
Sersté T, Mulkay JP, Nkuize M, Buset M
core  

Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites. [PDF]

, 2008
BACKGROUND: The Home Management of Malaria (HMM) strategy was developed using chloroquine, a now obsolete drug, which has been replaced by artemisinin-based combination therapy (ACT) in health facility settings.
Yusuf, Bidemi, Doamekpor, Leticia, Ikeoluwapo O Ajayi, Cousens, Simon, Fred Bateganya, Andrew Balyeku, Edmund N Browne, Peter Agyei-Baffour, Agyei-Baffour, Peter, Leticia Doamekpor, Browne, Edmund N, Kaendi Munguti, Balyeku, Andrew, Garshong, Bertha, Bertha Garshong, Franco Pagnoni, Bateganya, Fred, Pagnoni, Franco, Ajayi, Ikeoluwapo O, Simon Cousens, Munguti, Kaendi, Bidemi Yusuf   +21 more
core   +1 more source

Role of AURKB Inhibition in Reducing Proliferation and Enhancing Effects of Radiotherapy in Triple-Negative Breast Cancer

Breast Cancer: Targets and Therapy
Sierra Pellizzari,1 Harjot Athwal,1 Anne Claudine Bonvissuto,1,2 Armen Parsyan1– 4 1Department of Anatomy and Cell Biology, Western University, London, ON, Canada; 2Verspeeten Family Cancer Centre, London Health Sciences Centre, London, ON, Canada ...
Pellizzari S, Athwal H, Bonvissuto AC, Parsyan A   +3 more
doaj  

Efficacy of combination therapy of vitamin D and bisphosphonates in the treatment of postmenopausal osteoporosis: a systematic review and meta-analysis

Frontiers in Pharmacology
ObjectiveThere is currently no consensus on whether the combination therapy of Vitamin D (VitD) and bisphosphonates offers superior efficacy compared to monotherapy in the treatment of postmenopausal osteoporosis.
Yuangui Yang, Mingyue Yang, Xuanyi Su, Feibin Xie   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity. [PDF]

, 2008
BACKGROUND: Artemisinin derivatives used in recently introduced combination therapies (ACTs) for Plasmodium falciparum malaria significantly lower patient infectiousness and have the potential to reduce population-level transmission of the parasite. With
Drakeley, Chris J, Bousema, Teun, Lucy C Okell, Bousema, T, Ghani, Azra C, Drakeley Chris J, Drakeley, CJ, Christopher J M Whitty, Okell Lucy C, Bousema Teun, Okell, Lucy C, Azra C Ghani, Ghani, AC, Whitty Christopher J. M, Ghani Azra C, Teun Bousema, Whitty, Christopher JM, Okell, LC, Whitty, CJ, Christopher J. M Whitty, Chris J Drakeley   +20 more
core   +1 more source

Decitabine-Vorinostat combination treatment in acute myeloid leukemia activates pathways with potential for novel triple therapy

OncoTarget, 2017
Despite advancements in cancer therapeutics, acute myeloid leukemia patients over 60 years old have a 5-year survival rate of less than 8%. In an attempt to improve this, epigenetic modifying agents have been combined as therapies in clinical studies. In
Christine S. Young, Kathryn M. Clarke, Laura M. J. Kettyle, A. Thompson, K. Mills   +4 more
semanticscholar   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Saxagliptin and Metformin in Fixed Combination for the Treatment of Type 2 Diabetes in Adults

, 2013
Type 2 diabetes affects millions of people worldwide and significantly contributes to morbidity and mortality of those affected by it. Current guidelines recommend individualized treatment regimens following first line metformin therapy.
Mary S. Klein, Brian T. Terrell, Molly G. Minze   +2 more
core   +1 more source