Results 121 to 130 of about 28,100,614 (312)

Targeting Strategies for the Combination Treatment of Cancer Using Drug Delivery Systems

Pharmaceutics, 2017
Cancer cells have characteristics of acquired and intrinsic resistances to chemotherapy treatment—due to the hostile tumor microenvironment—that create a significant challenge for effective therapeutic regimens.
Janel L. Kydd, Rahul Jadia, Praveena Velpurisiva, Aniket P. Gad, Shailee Paliwal, P. Rai   +5 more
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review [PDF]

, 2007
Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of oxaliplatin in patients with ...
Pavlakis, Nick, Ross Davey, Davey, Ross, Nick Pavlakis, Britta Stordal, Stordal, Britta, Stordal, B., Pavlakis, N., Davey, R.   +8 more
core   +2 more sources

Real-world efficacy of lenvatinib/pembrolizumab combination in anaplastic thyroid carcinoma: case series from two Italian referral centers

European Thyroid Journal
Objective: Anaplastic thyroid carcinoma (ATC) is an extremely aggressive cancer, traditionally refractory to conventional treatments. The combined therapy with lenvatinib and pembrolizumab (L + P) is supported by a preclinical rationale based on the ...
Edoardo Talpacci, Manuela Macera, Giulia Maida, Silvia Morelli, Vincenzo Leone, Chiara Ingriccini, Antonella Ferrieri, Rachele Tortoriello, Miriam Paci, Monia Baldoni, Olivia Morelli, Samuele Barp, Marialuisa Sponziello, Marianna Maranghi, Cosimo Durante, Giorgio Grani, Efisio Puxeddu   +16 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Artemisinin-based combination therapies (ACTs): best hope for malaria treatment but inaccessible to the needy!

, 2005
Artemisinin-based combination therapies (ACTs) are the best anti-malarial drugs available now. Artemisinin enhances efficacy and has the potential of lowering the rate at which resistance emerges and spreads.
Mutabingwa, TK
core   +1 more source

Who Gets Prompt Access to Artemisinin-based Combination Therapy? A Prospective Community-Based Study in Children from Rural Kilosa, Tanzania. [PDF]

, 2010
Effective and timely case management remains one of the fundamental pillars for control of malaria. Tanzania introduced artemisinin-combination therapy [ACT] for uncomplicated malaria; however, the policy change is challenged by limited availability of ...
Zul Premji, Zakayo Mrango, Simba, D.O., Marian Warsame, Tomson, G., Goran Tomson, Kakoko, Deodatus, Deodatus Kakoko, Petzold, M., Tomson, Goran, Premji, Z., Premji Zul, Premji, Zul, Mrango, Z., Simba, Daudi O, Petzold, Max, Warsame, Marian, Petzold Max, Daudi O. Simba, Warsame Marian, Tomson Goran, Warsame, M., Max Petzold, Simba Daudi O., Mrango, Zakayo, Mrango Zakayo, Kakoko, D., Daudi O Simba, Kakoko Deodatus   +28 more
core   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Piloting the global subsidy: the impact of subsidized artemisinin-based combination therapies distributed through private drug shops in rural Tanzania. [PDF]

, 2009
BACKGROUND: WHO estimates that only 3% of fever patients use recommended artemisinin-based combination therapies (ACTs), partly reflecting their high prices in the retail sector from where many patients seek treatment.
Catherine Goodman, Ward Lorrayne, Mwita, Alex, Oliver J Sabot, Odhiambo, Moses, Odhiambo Moses, Ipuge, Yahya, Sabot Oliver J., Cohen Justin M., Gordon Megumi, Bishop David, Justin M Cohen, Bishop, David, Moses Odhiambo, Megumi Gordon, Goodman Catherine, Ipuge Yahya, Gordon, Megumi, Cohen, Justin M, Sabot, Oliver J, Lorrayne Ward, Ward, Lorrayne, Mwita Alex, Goodman, Catherine, David Bishop, Yahya Ipuge, Alex Mwita   +26 more
core   +2 more sources

Synergistic Inhibition of Mycotoxigenic Fungi and Mycotoxin Production by Combination of Pomegranate Peel Extract and Azole Fungicide

Frontiers in Microbiology, 2019
Fungal plant pathogens cause considerable losses in yield and quality of field crops worldwide. In addition, under specific environmental conditions, many fungi, including such as some Fusarium and Aspergillus spp., are further able to produce mycotoxins
Sudharsan Sadhasivam, Orr H. Shapiro, Carmit Ziv, Omer Barda, Varda Zakin, Edward Sionov   +5 more
doaj   +1 more source