Results 111 to 120 of about 28,100,614 (312)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Hepatitis C viral evolution in genotype 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy in clinical trials [PDF]

, 2012
Background: In patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased sustained virologic response (SVR) rates compared with PR alone.
Bambang Adiwijaya, Joan Spanks, Ann Tigges (171451), Ann Tigges, Joan Spanks (171460), Zhang Eileen Z., Maria Beumont, Bartels Doug J., De Meyer, Sandra, Jacobson, Ira M., Ira M. Jacobson (171497), Kieffer Tara L., Ghys Anne, Min Jiang, Sullivan James C., James C Sullivan, Doug J Bartels, Beumont, Maria, Dorrian Jennifer, Dierynck, Inge, Nathalie Adda, Adiwijaya, Bambang, Kauffman, Robert S., Kwong, Ann D., Min Jiang (56794), Jennifer Dorrian (171464), James C. Sullivan (13811), Bambang Adiwijaya (171470), Sherman, Kenneth E., Dierynck Inge, Ann D. Kwong (171515), Ghys, Anne, Tara L Kieffer, Gaston Picchio, Maria Beumont (171481), Spanks Joan, Inge Dierynck, Kenneth E Sherman, Robert S Kauffman, Adda Nathalie, Sherman Kenneth E., Stefan Zeuzem (22856), Stefan Zeuzem, Inge Dierynck (171456), Jiang, Min, Robert S. Kauffman (171487), Gaston Picchio (171523), Kwong Ann D., Zhang, Eileen Z., Sandra De Meyer (171427), Tigges, Ann, Zeuzem Stefan, Dorrian, Jennifer, Kenneth E. Sherman (171505), Sandra De Meyer, Nathalie Adda (171493), Jacobson Ira M., Adiwijaya Bambang, Ira M Jacobson, Bartels, Doug J., Doug J. Bartels (171434), Eileen Z Zhang, Jennifer Dorrian, De Meyer Sandra, Tigges Ann, Sullivan, James C., Picchio, Gaston, Ann D Kwong, Anne Ghys (171476), Adda, Nathalie, Eileen Z. Zhang (171445), Kieffer, Tara L., Spanks, Joan, Picchio Gaston, Kauffman Robert S., Anne Ghys, Tara L. Kieffer (171419), Jiang Min, Zeuzem, Stefan, Beumont Maria   +79 more
core   +1 more source

Priority Setting for the Implementation of Artemisinin-Based Combination Therapy Policy in Tanzania: Evaluation Against the Accountability for Reasonableness Framework. [PDF]

, 2012
\ud Priority setting for artemisinin-based antimalarial drugs has become an integral part of malaria treatment policy change in malaria-endemic countries. Although these drugs are more efficacious, they are also more costly than the failing drugs.
Mori Amani, Kaale, E.A., Mori, Amani Thomas, Amani Thomas Mori, Kaale, Eliangiringa Amos, Mori, A.T., Kaale Eliangiringa, Eliangiringa Amos Kaale   +7 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

What is the best combination treatment with transarterial chemoembolization of unresectable hepatocellular carcinoma? a systematic review and network meta-analysis

OncoTarget, 2017
Objective To assess the comparative efficacy and safety of combination treatment with transarterial chemoembolization (TACE) for patients with unresectable hepatocellular carcinoma (HCC) through a systematic review and network meta-analysis and to ...
Hui Xie, Hai-Peng Yu, Shengtao Tian, Xue-Ling Yang, Xi-Ming Wang, Zhao Yang, Hua-Ming Wang, Zhi Guo   +7 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Tumor-targeted polymeric nanostructured lipid carriers with precise ratiometric control over dual-drug loading for combination therapy in non-small-cell lung cancer

International Journal of Nanomedicine, 2017
Yan Liang,1 Baocheng Tian,1 Jing Zhang,1 Keke Li,1 Lele Wang,1 Jingtian Han,1,* Zimei Wu2,* 1School of Pharmacy, Binzhou Medical University, 2School of Pharmacy, Yantai University, Yantai, China *These authors contributed equally to this work Abstract:
Liang Y, Tian B, Zhang J, Li K, Wang L, Han J, Wu Z   +6 more
doaj  

Harnessing NKG2D CAR-T cells with radiotherapy: a novel approach for esophageal squamous cell carcinoma treatment

Frontiers in Immunology
BackgroundEsophageal squamous cell carcinoma (ESCC) represents a highly aggressive malignancy with poor prognosis and limited therapeutic advancements.
Tianyu Liu, Tianyu Liu, Tianyu Liu, Liyuan Fan, Liyuan Fan, Liyuan Fan, Weicheng Huang, Weicheng Huang, Pengxiang Chen, Pengxiang Chen, Yuchen Liu, Yuchen Liu, Shuyun Wang, Kaiyue Guo, Kaiyue Guo, Yufeng Cheng, Yufeng Cheng, Yali Han, Yali Han, Yali Han   +19 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An antibiotic-free antimicrobial combination of bacteriocins and a peptidoglycan hydrolase: in vitro and in vivo assessment of its efficacy

Applied and Environmental Microbiology
Mastitis is an inflammatory disease of the mammary gland usually caused by bacterial pathogens that gain physical access to the glandular epithelium through the teat canal.
Christian Kranjec, Thomas F. Oftedal, Kirill V. Ovchinnikov, Vinícius da Silva Duarte, Simen Hermansen, Magdalena Kaus-Drobek, Izabela Sabała, Davide Porcellato, Harald Carlsen, Morten Kjos   +9 more
doaj   +1 more source