Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Protein-Directed Dynamic Combinatorial Chemistry: An Efficient Strategy in Drug Design. [PDF]
ACS Omega, 2020 Canal-Martín A, Pérez-Fernández R.
europepmc +1 more source
Papers on combinatorial chemistry or solid-phase synthesis from other journals - March 1999
, 1999 openalex +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Static Combinatorial Chemistry: A High-Pressure Approach to the Synthesis of Macrocyclic Benzoamide Libraries. [PDF]
ACS Comb Sci, 2020 Pikus G, Tyszka-Gumkowska A, Jurczak J.
europepmc +1 more source
Papers on combinatorial chemistry or solid-phase synthesis from other journals - September 1998
, 1998 openalex +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Support Vector Machines in Combinatorial Chemistry
Measurement + Control, 2001 Matthew W B Trotter +2 more
doaj +1 more source
One-Pot Parallel Synthesis of Unclosed Cryptands-Searching for Selective Anion Receptors via Static Combinatorial Chemistry Techniques. [PDF]
ACS Omega, 2020 Niedbała P, Jurczak J.
europepmc +1 more source