The dark side of disulfide-based dynamic combinatorial chemistry. [PDF]
Dumartin M +7 more
europepmc +1 more source
Activation of C-H Bonds α to Nitriles for Combinatorial Chemistry: Ruthenium-Catalyzed Aldol and Michael Reactions of Polymer-Supported Nitriles [PDF]
Hikaru Takaya, Shun‐Ichi Murahashi
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Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Localized template-driven functionalization of nanoparticles by dynamic combinatorial chemistry.
P. Nowak +5 more
semanticscholar +1 more source
The integration of functional genomics, combinatorial chemistry and nanotechnology into a miniaturized drug discovery process [PDF]
Manfred Auer
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In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Buchbesprechung: Analytical Techniques in Combinatorial Chemistry. Von Michael E. Swartz. [PDF]
Jörg W. Metzger
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Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Book Review: Combinatorial Chemistry - A Practical Approach. Edited by Willi Bannwarth and Eduard Felder. Volume 9 in the series Methods and Principles in Medicinal Chemistry, edited by R. Mannhold, H. Kubinyi, H. Timmermann. [PDF]
Matthias Lormann, Stefan Bräse
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