Results 201 to 210 of about 36,490 (240)

Combinatorial chemistry in the agrosciences

Bioorganic & Medicinal Chemistry, 2009
Combinatorial chemistry and high throughput screening have had a profound effect upon the way in which agrochemical companies conduct their lead discovery research. The article reviews recent applications of combinatorial synthesis in the lead discovery process for new fungicides, herbicides and insecticides.
Stephen D, Lindell, Lisa C, Pattenden, Jonathan, Shannon   +2 more
openaire   +2 more sources

Microfluidic combinatorial chemistry

Current Opinion in Chemical Biology, 2003
Microreactors are finding increasing application in the field of combinatorial chemistry. In the past few years, microreactor chemistry has shown great promise as a novel method on which to build new chemical technology and processes. It has been conclusively demonstrated that reactions performed within microreactors invariably generate relatively pure
Paul, Watts, Stephen J, Haswell
openaire   +2 more sources

Dynamic combinatorial chemistry

Drug Discovery Today, 2002
A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this. In this review, we will highlight the unique features that distinguish dynamic combinatorial chemistry from traditional ...
Sijbren, Otto, Ricardo L E, Furlan, Jeremy K M, Sanders   +2 more
openaire   +2 more sources

Basics of Combinatorial Chemistry

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Cécile Vanier, Alain Wagner
openaire   +1 more source

Overview of Combinatorial Chemistry

Current Protocols in Pharmacology, 2000
AbstractThis unit provides an overview of combinatorial chemistry, including the design and construction of combinatorial libraries for drug discovery. Strategies and resources for library synthesis are summarized, and examples of combinatorial libraries are given.
S L, Crooks, L J, Charles
openaire   +2 more sources

Nanotiterplates for combinatorial chemistry

Reviews in Molecular Biotechnology, 2001
Miniaturization has grown to be a driving force in modern chemical and biochemical laboratories. Combinatorial explosion demands for new pathways for the synthesis and screening of new substances which can act as leads in drug discovery. Highly parallelized automata that can handle the smallest amounts of substances are needed. However, the development
G, Mayer, A, Schober, J M, Köhler
openaire   +2 more sources

Steroids and Combinatorial Chemistry

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
René, Maltais, Martin R, Tremblay, Liviu C, Ciobanu, Donald, Poirier   +3 more
openaire   +2 more sources

Dynamic Combinatorial Chemistry

Combinatorial Chemistry & High Throughput Screening, 1970
Dynamic combinatorial chemistry is based on the reversible combination of initial building blocks to form dynamic combinatorial libraries. It has recently emerged as an efficient strategy to detect and to evaluate affinity between the library products and a target molecule.
I, Huc, R, Nguyen
openaire   +2 more sources

Solid supports for combinatorial chemistry

Current Opinion in Chemical Biology, 2002
Over the past year, numerous techniques have been used to study the resins commonly utilised in solid-phase synthesis to allow a greater understanding of the chemical nature and the physical properties of the supports. In addition, to overcome some of the drawbacks of existing materials, several new resins and new methods of handling solid supports ...
Zhanru, Yu, Mark, Bradley
openaire   +2 more sources

Combinatorial Chemistry in Glycobiology

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +2 more sources