Results 191 to 200 of about 1,144,978 (368)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry. [PDF]

Chem Commun (Camb), 2020
Umuhire Juru A, Cai Z, Jan A, Hargrove AE.   +3 more
europepmc   +1 more source

Identification of peptide superagonists using combinatorial chemistry and mass spectrometry

, 2000
Sho Matsushita, Hideki Ohyama, Yoshihiko Tanaka   +2 more
openalex   +2 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Enzyme-Mediated Dynamic Combinatorial Chemistry Enables Large-Scale Synthesis of δ-Cyclodextrin. [PDF]

J Am Chem Soc
Hansen KH, Erichsen A, Larsen D, Beeren SR.   +3 more
europepmc   +1 more source

Polymer-Supported Reagents as Versatile Tools in Combinatorial Chemistry and Total Synthesis

, 2000
Steven V. Ley, Gloria Brusotti, Marina Caldarelli, Jörg Habermann, James S. Scott   +4 more
openalex   +1 more source

Combinatorial chemistry

Current Opinion in Chemical Biology, 2005
Arya, Prabhat, Roth, Hans-Jörg
openaire   +4 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Dynamic Combinatorial Chemistry Generates Adaptative Libraries of Glyco-Dyn[n]Arenes That can Be Templated to Produce Anti-Adhesive Glycoconjugates Targeting Pseudomonas aeruginosa. [PDF]

Chemistry
Demontrond F, Pascal Y, Donnier-Maréchal M, Raillon C, Luton B, Tramblais C, Vial L, Gueyrard D, Galia W, Berger E, Géloën A, Cournoyer B, Leclaire J, Vidal S.   +13 more
europepmc   +1 more source

Discovery of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions via Dynamic Combinatorial Chemistry. [PDF]

ACS Med Chem Lett, 2020
Hartman AM, Elgaher WAM, Hertrich N, Andrei SA, Ottmann C, Hirsch AKH.   +5 more
europepmc   +1 more source