Results 191 to 200 of about 1,152,460 (369)

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Combinatorial Chemistry at Lead Finding

CHIMIA, 1997
Rudolf Giger
doaj   +2 more sources

Chirality Effects in Peptide-Based Dynamic Combinatorial Chemistry. [PDF]

Chemistry
Gable A, Pohjolainen E, Groenhof G, Cougnon FBL.   +3 more
europepmc   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry. [PDF]

Chem Commun (Camb), 2020
Umuhire Juru A, Cai Z, Jan A, Hargrove AE.   +3 more
europepmc   +1 more source

Identification of peptide superagonists using combinatorial chemistry and mass spectrometry

, 2000
Sho Matsushita, Hideki Ohyama, Yoshihiko Tanaka   +2 more
openalex   +2 more sources

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Enzyme-Mediated Dynamic Combinatorial Chemistry Enables Large-Scale Synthesis of δ-Cyclodextrin. [PDF]

J Am Chem Soc
Hansen KH, Erichsen A, Larsen D, Beeren SR.   +3 more
europepmc   +1 more source

Polymer-Supported Reagents as Versatile Tools in Combinatorial Chemistry and Total Synthesis

, 2000
Steven V. Ley, Gloria Brusotti, Marina Caldarelli, Jörg Habermann, James S. Scott   +4 more
openalex   +1 more source

Combinatorial chemistry

Current Opinion in Chemical Biology, 2005
Arya, Prabhat, Roth, Hans-Jörg
openaire   +4 more sources