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Stringent selection on kinetics of condensation reactions: early steps in chemical evolution.
Phys Chem Chem PhysCapera-Aragones P +6 more
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Combinatorial Carbohydrate Chemistry
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Marcaurelle, L., Seeberger, P.
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Dynamic combinatorial chemistry
Drug Discovery Today, 2002A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this. In this review, we will highlight the unique features that distinguish dynamic combinatorial chemistry from traditional ...
Sijbren, Otto +2 more
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Dynamic Combinatorial Chemistry
Combinatorial Chemistry & High Throughput Screening, 1970Dynamic combinatorial chemistry is based on the reversible combination of initial building blocks to form dynamic combinatorial libraries. It has recently emerged as an efficient strategy to detect and to evaluate affinity between the library products and a target molecule.
I, Huc, R, Nguyen
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Dynamic Combinatorial Chemistry
Science, 2001By combining the advantages of combinatorial chemistry and supramolecular chemistry, dynamic combinatorial chemistry may become a powerful tool for drug discovery and materials science. In their Perspective, Lehn and Eliseev chart some of the recent progress in this field.
J M, Lehn, A V, Eliseev
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Microfluidic combinatorial chemistry
Current Opinion in Chemical Biology, 2003Microreactors are finding increasing application in the field of combinatorial chemistry. In the past few years, microreactor chemistry has shown great promise as a novel method on which to build new chemical technology and processes. It has been conclusively demonstrated that reactions performed within microreactors invariably generate relatively pure
Paul, Watts, Stephen J, Haswell
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Combinatorial chemistry of hydantoins
Bioorganic & Medicinal Chemistry Letters, 1998Access to combinatorial chemistry of hydantoins is provided by convenient and versatile methods for the solid phase synthesis of libraries of 3,5-, 1,3- and 1,3,5-substituted hydantoins. The preparation of trisubstituted hydantoins features a Mitsunobu reaction for introduction of the substituent on N-1.
Boeijen, A. +2 more
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Combinatorial Carbohydrate Chemistry
1998Modern organic/medicinal chemistry is undergoing a “cultural revolution” in the way new drugs are discovered and developed. Instead of discrete synthess and biological screening of individual compounds, which often takes years to identify and optimize leads, the currently developing technology called “combinatorial chemistry” can rapidly provide large ...
Z G, Wang, O, Hindsgaul
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