Results 231 to 240 of about 42,234 (281)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Mapping the Substrate Specificity Landscape of PAD2 and PAD4 Enzymes. [PDF]

open access: yesChembiochem
Borbély A   +6 more
europepmc   +1 more source

Stringent selection on kinetics of condensation reactions: early steps in chemical evolution.

open access: yesPhys Chem Chem Phys
Capera-Aragones P   +6 more
europepmc   +1 more source

Dynamic Combinatorial Chemistry [PDF]

open access: yesChemical Reviews, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Peter T Corbett   +2 more
exaly   +4 more sources

Dynamic combinatorial chemistry

open access: yesDrug Discovery Today, 2002
A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this. In this review, we will highlight the unique features that distinguish dynamic combinatorial chemistry from traditional ...
Sijbren, Otto   +2 more
openaire   +3 more sources

Combinatorial chemistry of hydantoins

Bioorganic & Medicinal Chemistry Letters, 1998
Access to combinatorial chemistry of hydantoins is provided by convenient and versatile methods for the solid phase synthesis of libraries of 3,5-, 1,3- and 1,3,5-substituted hydantoins. The preparation of trisubstituted hydantoins features a Mitsunobu reaction for introduction of the substituent on N-1.
Boeijen, A.   +2 more
openaire   +3 more sources

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