Results 231 to 240 of about 72,837 (274)
In Silico Optimization of Inhibitors of the 3-Chymotrypsin-like Protease of SARS-CoV-2. [PDF]
Life (Basel)Fofana I +6 more
europepmc +1 more source
Combinatorial chemistry synthesis techniques
Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136), 2002 As pharmaceutical companies race to find new and novel drugs faster, the tools of combinatorial chemistry are increasingly playing a larger role. Chemists can now prepare hundreds or thousands of analogs simultaneously to reveal structure-activity relationships (SAR) all at once and potentially shorten the discovery process for new drugs by years.
Michael L. Vazquez
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Combinatorial Chemistry Techniques Applied to Nonpeptide lntegrin Antagonists
Current Medicinal Chemistry, 1998 The integrins are cell surface receptors that recognize extracellular matrix adhesive proteins such as fibrinogen, fibronectin, vitronectin, and VCAM-1 (vascular cell adhesion molecule-1). Nonpeptide integrin antagonists designed after the adhesion recognition sequence RGD (Arg-Giy-Asp) not only have displayed efficacy as antithrombotic ...
W J, Hoekstra, B L, Poulter
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High-resolution NMR techniques for solid-phase synthesis and combinatorial chemistry
Drug Discovery Today, 1997 Recent developments in NMR spectroscopy have created two complementary categories of analysis for drug discovery processes. The first category includes techniques for obtaining high-resolution (especially 1H) NMR spectra of compounds still bound to solid-phase synthesis resins.
Paul A. Keifer
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Journal of the American Chemical Society, 1996 Infrared microspectroscopy has been developed as a powerful, nondestructive technique for the quantitative analysis of solid-phase, resin-bound chemical reactions. The synthesis and/or application of deuterium isotope containing protecting groups, including acetyl-d3 chloride, benzoyl-d5 chloride, and 2-[[[(tert-butyl-d9)oxy]carbonyl]oximino]-2 ...
Keith Russell +3 more
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ChemInform Abstract: Organic Combinatorial Chemistry: Concepts, Terms and Basic Techniques
ChemInform, 2001 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Massimo Massimo
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ChemInform Abstract: Resin Capture Techniques in Combinatorial Chemistry
ChemInform, 2000 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Chucholowski, M. Nettekoven
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ChemInform Abstract: Combinatorial Chemistry Techniques Applied to Nonpeptide Integrin Antagonists
ChemInform, 1998 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
W. J. HOEKSTRA, B. L. POULTER
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Journal of Chemical Information and Computer Sciences, 1998 The use of combinatorial chemistry for the generation of new lead molecules is now a well established strategy in the drug discovery process. Central to the use of combinatorial chemistry is the design and availability of high quality building blocks which are likely to afford hits from the libraries that they generate.
X Q, Lewell +3 more
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ChemInform, 1998 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Paul A. Keifer
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