Results 51 to 60 of about 72,837 (274)
Single Domain Antibodies as New Biomarker Detectors
Diagnostics, 2017 Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow +5 more
doaj +1 more source
Experimental library screening demonstrates the successful application of computational protein design to large structural ensembles [PDF]
, 2010 The stability, activity, and solubility of a protein sequence are determined by a delicate balance of molecular interactions in a variety of conformational states.
A. Nisthal +41 more
core +3 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Natural product-like combinatorial libraries
Journal of the Brazilian Chemical Society, 2003 Combinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a ...
Abreu Pedro M., Branco Paula S.
doaj
Education SciencesCurrent higher education trends are moving towards interdisciplinary curricula to provide new tools for solving complex issues. However, course design and learning tracks still create divisions between scientific disciplines. This study aimed to evaluate
Nadav Badrian +3 more
doaj +1 more source
, 2015 The development of new engineering alloy chemistries is a time consuming and iterative process. A necessary step is characterization of the nano/microstructure to provide a link between the processing and properties of each alloy chemistry considered ...
De Geuser, F. +3 more
core +3 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Current Perspectives on Aptamers as Diagnostic Tools and Therapeutic Agents
Pharmaceutics, 2020 Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial oligonucleotide libraries through the well-known in vitro selection and iteration process, SELEX.
Prabir Kumar Kulabhusan +2 more
doaj +1 more source
Combinatorial Space Tiling [PDF]
, 2010 The present article studies combinatorial tilings of Euclidean or spherical spaces by polytopes, serving two main purposes: first, to survey some of the main developments in combinatorial space tiling; and second, to highlight some new and some old open ...
Schulte, Egon
core
A Study of NK Landscapes' Basins and Local Optima Networks [PDF]
, 2008 We propose a network characterization of combinatorial fitness landscapes by adapting the notion of inherent networks proposed for energy surfaces (Doye, 2002). We use the well-known family of $NK$ landscapes as an example.
Darabos, Christian +3 more
core +4 more sources