Results 51 to 60 of about 172,692 (298)
Virtual Ligand Screening for Structure-based Drug Design: Approaches and Progress [PDF]
Bioautomation, 2007 Recent progress in human genomics and proteomics has significantly increased the number of macromolecular targets potentially involved in drug discovery campaigns.
Olivier Sperandio +2 more
doaj
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Single Domain Antibodies as New Biomarker Detectors
Diagnostics, 2017 Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow +5 more
doaj +1 more source
Multivalent glycan arrays [PDF]
, 2019 Glycan microarrays have become a powerful technology to study biological processes, such as cell–cell interaction, inflammation, and infections. Yet, several challenges, especially in multivalent display, remain.
Bordoni, Vittorio +5 more
core +1 more source
Natural product-like combinatorial libraries
Journal of the Brazilian Chemical Society, 2003 Combinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a ...
Abreu Pedro M., Branco Paula S.
doaj
Education SciencesCurrent higher education trends are moving towards interdisciplinary curricula to provide new tools for solving complex issues. However, course design and learning tracks still create divisions between scientific disciplines. This study aimed to evaluate
Nadav Badrian +3 more
doaj +1 more source
, 2015 The development of new engineering alloy chemistries is a time consuming and iterative process. A necessary step is characterization of the nano/microstructure to provide a link between the processing and properties of each alloy chemistry considered ...
De Geuser, F. +3 more
core +3 more sources
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Current Perspectives on Aptamers as Diagnostic Tools and Therapeutic Agents
Pharmaceutics, 2020 Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial oligonucleotide libraries through the well-known in vitro selection and iteration process, SELEX.
Prabir Kumar Kulabhusan +2 more
doaj +1 more source
Combinatorial Space Tiling [PDF]
, 2010 The present article studies combinatorial tilings of Euclidean or spherical spaces by polytopes, serving two main purposes: first, to survey some of the main developments in combinatorial space tiling; and second, to highlight some new and some old open ...
Schulte, Egon
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