Results 61 to 70 of about 1,181,281 (295)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Impact Evaluation of Prefabricated Buildings Cost on Game Theory-Cloud Model

Journal of Mathematics, 2022
Prefabricated buildings have the advantages of energy-saving, high efficiency, and high quality, which is energetically promoted in China’s construction industry.
Na Li, Zhifeng Fan
doaj   +1 more source

Solving Probabilistic Combinatorial Games [PDF]

, 2006
Probabilistic combinatorial games (PCGs) are a model for Go-like games recently introduced by Ken Chen. They differ from normal combinatorial games since terminal positions in each subgame are evaluated by a probability distribution. The distribution expresses the uncertainty in the local evaluation.
Ling Zhao, Martin Müller 0003
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Games of Nim with Dynamic Restrictions

Indonesian Journal of Combinatorics
The authors present formulas for the previous player’s winning positions of two variants of restricted Nim. In both of these two games, there is one pile of stones, and in the first variant, we investigate the case that in k-th turn, you can remove f(k ...
Keita Mizugaki, Shoei Takahashi, Hikaru Manabe, Aoi Murakami, Ryohei Miyadera   +4 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Playing cards: spatial arrangements for observational learning

Psychology of Language and Communication, 2018
This paper looks at how players of a card game create spatial arrangements of playing cards, and the cognitive and communicative effects of such arrangements.
Maare Åsa Harvard
doaj   +1 more source

LP-games and combinatorial optimization games [PDF]

Cahiers du Centre d'Études de Recherche Opérationnelle, 1992
Summary: A survey is given of combinatorial optimization game theory. In more detail flow games and linear production games are treated.
openaire   +5 more sources

Combinatorial Game Distributions of Steiner Systems [PDF]

The Electronic Journal of Combinatorics, 2021
The $P$-position sets of some combinatorial games have special combinatorial structures. For example, the $P$-position set of the hexad game, first investigated by Conway and Ryba, is the block set of the Steiner system $S(5, 6, 12)$ in the shuffle numbering, denoted by $D_{\text{sh}}$.
openaire   +4 more sources