Results 121 to 130 of about 39,679 (279)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Dynamic Combinatorial Optimization of In Vitro and In Vivo Heparin Antidotes. [PDF]

J Med Chem, 2022
Carbajo D, Pérez Y, Guerra-Rebollo M, Prats E, Bujons J, Alfonso I.   +5 more
europepmc   +1 more source

Machine learning at the service of meta-heuristics for solving combinatorial optimization problems: A state-of-the-art

, 2021
Maryam Karimi-Mamaghan, Mehrdad Mohammadi, Patrick Meyer, Amir Mohammad Karimi-Mamaghan, El‐Ghazali Talbi   +4 more
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A droplet-based microfluidic platform enables high-throughput combinatorial optimization of cyanobacterial cultivation. [PDF]

Sci Rep, 2022
Cao J, Russo DA, Xie T, Groß GA, Zedler JAZ.   +4 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Combinatorial optimization by weight annealing in memristive hopfield networks. [PDF]

Sci Rep, 2021
Fahimi Z, Mahmoodi MR, Nili H, Polishchuk V, Strukov DB.   +4 more
europepmc   +1 more source

Introduction to Combinatorial Optimization: Model Building in Integer Programming

, 2014
Shunji Umetani
openalex   +2 more sources

Completion Time Minimization in NOMA Systems: Learning for Combinatorial Optimization

, 2021
Anyue Wang, Lei Lei, Eva Lagunas, Symeon Chatzinotas, Björn Ottersten   +4 more
openalex   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source