Results 71 to 80 of about 4,882,239 (315)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Nuevas técnicas de particionamiento en clasificación automática
Revista de Matemática: Teoría y Aplicaciones, 2009 In this article there are exposed some new thechniques for hte search of global optima inthe partitioning problem in Cluster Analysis. With these thechniques the results are sensibly improved with respect to the traditional methods. The methods developed
Eduardo Piza Volio +2 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Multi-objective Discrete Combinatorial Optimization Algorithm Combining Problem-Decomposition and Adaptive Large Neighborhood Search [PDF]
Jisuanji kexue yu tansuoIn order to efficiently obtain solutions for large-scale multi-objective optimization problems in reality, to achieve a balance among convergence, diversity, and uniformity has gradually become one of the important goals in multi-objective optimization ...
WEI Qian, JI Bin
doaj +1 more source
New Core-Guided and Hitting Set Algorithms for Multi-Objective Combinatorial Optimization [PDF]
, 2022 João Cortes +2 more
openalex +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
State Transition Simulated Annealing Algorithm for Discrete-Continuous Optimization Problems
IEEE Access, 2019 A simulated annealing (SA) algorithm is an effective method for solving optimization problems, especially for combinatorial optimization problems. However, SA algorithms rely heavily on the iterative mechanism of the neighborhood structure.
Xiaoxia Han +3 more
doaj +1 more source
Quantum Dueling: an Efficient Solution for Combinatorial Optimization [PDF]
, 2023 Letian Tang +5 more
openalex +1 more source