Results 41 to 50 of about 33,492 (302)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Cross entropy-based memetic algorithms: An application study over the tool switching problem [PDF]
International Journal of Computational Intelligence Systems, 2013 This paper presents a parameterized schema for building memetic algorithms based on cross-entropy (CE) methods. This novel schema is general in nature, and features multiple probability mass functions and Lamarckian learning.
Jhon Edgar Amaya +2 more
doaj +1 more source
A Combinatorial Lemma and its Application to Probability Theory [PDF]
Transactions of the American Mathematical Society, 1956 To explain the idea behind the present paper the following fundamental principle is emphasized. Let X = (X 1,…, X n ) be an n-dimensional vector valued random variable, and let µ(x) =µ(x 1…, x n )be its probability measure (defined on euclidean n-space E n ).
openaire +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
مجلة بغداد للعلوم, 2016 The substantial key to initiate an explicit statistical formula for a physically specified continua is to consider a derivative expression, in order to identify the definitive configuration of the continua itself. Moreover, this statistical formula is to
Baghdad Science Journal
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
A combinatorial identity and its application to Gaussian measures [PDF]
, 2007 Assuming that a probability measure on ℝd has finite moments of any order, its moments are completely determined by two family of operators. The first family is composed of the neutral (preservation) operators.
Kuo, HH +4 more
core +1 more source
A General Combinatorial Ant System-based Distributed Routing Algorithm for Communication Networks [PDF]
Journal of Systemics, Cybernetics and Informatics, 2007 In this paper, a general Combinatorial Ant System-based distributed routing algorithm modeled like a dynamic combinatorial optimization problem is presented.
Jose Aguilar, Miguel Labrador
doaj
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Combinatorics And The Development Of Children's Combinatorial Reasoning
, 2005 This chapter begins by exploring some elementary ideas of combinatorics and how they support children’s development of beginning probability ideas and problem-solving skills.
English, Lyn D.
core +1 more source