Results 51 to 60 of about 29,779 (262)

SINGULARITY OF RANDOM SYMMETRIC MATRICES—A COMBINATORIAL APPROACH TO IMPROVED BOUNDS

open access: yesForum of Mathematics, Sigma, 2019
Let $M_{n}$ denote a random symmetric $n\times n$ matrix whose upper-diagonal entries are independent and identically distributed Bernoulli random variables (which take values $1$ and $-1$ with probability $1/2$ each). It is widely conjectured that $M_{n}
ASAF FERBER, VISHESH JAIN
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

THE EXPECTED JAGGEDNESS OF ORDER IDEALS

open access: yesForum of Mathematics, Sigma, 2017
The jaggedness of an order ideal $I$ in a poset $P$ is the
MELODY CHAN   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Numerous but rare: an exploration of magic squares. [PDF]

open access: yesPLoS ONE, 2015
How rare are magic squares? So far, the exact number of magic squares of order n is only known for n ≤ 5. For larger squares, we need statistical approaches for estimating the number.
Akimasa Kitajima, Macoto Kikuchi
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Study of Random Biased d-ary Tries Model

open access: yesپژوهش‌های ریاضی, 2016
Tries are the most popular data structure on strings. We can construct d-ary tries by using strings over an alphabet leading to d-ary tries. Throughout the paper we assume that strings stored in trie are generated by an appropriate memory less source. In
r kazemi, h. abdolahinohoji, s norouzi
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A combinatorial problem related to the classical probability

open access: yesDiscrete Mathematics
In the classical probability model, let $f(n)$ be the maximum number of pairwise independent events for the sample space with $n$ sample points. The determination of $f(n)$ is equivalent to the problem of determining the maximum cardinality of specific intersecting families on the set $\{1,2,\ldots,n\}$ .
openaire   +3 more sources

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