Results 61 to 70 of about 29,779 (262)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Probability and Problems in Euclidean Combinatorial Optimization

Statistical Science, 1993
This article summarizes the current status of several streams of research that deal with the probability theory of problems of combina- torial optimization. There is a particular emphasis on functionals of finite point sets. The most famous example of such functionals is the length associated with the Euclidean traveling salesman problem (TSP), but ...
openaire   +3 more sources

Exploring the Higher-Order Moment Behavior of Certain Probability Distributions by Combinatorial and Asymptotic Analysis

Mathematics
For the binomial, Poisson and normal distributions, the n-th central-raw ratios E(ξ−Eξ)n/Eξn are known to be infinitesimal with distinct patterns.
Ping Sun, Chen Xu
doaj   +1 more source

Distribution of the combinatorial multisets component vectors

Lietuvos Matematikos Rinkinys, 2012
We explore a class of random combinatorial structures called weighted multisets. Their components are taken from an initial set satisfying general boundedness conditions posed on the number of elements with a given weight.
Eugenijus Manstavičius, Robertas Petuchovas   +1 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A New Triangular Probability Model: A Combinatorial Modification of Probability Distributions

African Journal of Mathematics and Statistics Studies
The paper projects innovating means to probability modeling using integration method and the concept of normalization. It brings to light a probability distribution obtained by combining a probability density function of a distribution and a cumulative distribution function of another continuous probability model, to produce a triangular trend and a ...
E. K. Guobadia, J. E. Okoh, I. E. Joel, A. M. Ajibola   +3 more
openaire   +1 more source

Efficient Quantum Answer Set Programming Solver Using Partial Diffusion and Entanglement

IEEE Access
The relation between answer set programming (ASP) and combinatorial problems, especially the satisfiability problem (SAT), has attracted significant interest in the academic literature.
Esraa Ebdelrehime, Ahmed Younes, Islam Elkabani   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source