Results 71 to 80 of about 1,317,810 (296)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A combinatorial problem related to the classical probability
Discrete MathematicsIn the classical probability model, let $f(n)$ be the maximum number of pairwise independent events for the sample space with $n$ sample points. The determination of $f(n)$ is equivalent to the problem of determining the maximum cardinality of specific intersecting families on the set $\{1,2,\ldots,n\}$ .
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Probability and Problems in Euclidean Combinatorial Optimization
Statistical Science, 1993 This article summarizes the current status of several streams of research that deal with the probability theory of problems of combina- torial optimization. There is a particular emphasis on functionals of finite point sets. The most famous example of such functionals is the length associated with the Euclidean traveling salesman problem (TSP), but ...
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
New techniques for cost sharing in combinatorial optimization games [PDF]
, 2010 Combinatorial optimization games form an important subclass of cooperative games. In recent years, increased attention has been given to the issue of finding good cost shares for such games.
Caprara, A +3 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
MathematicsFor the binomial, Poisson and normal distributions, the n-th central-raw ratios E(ξ−Eξ)n/Eξn are known to be infinitesimal with distinct patterns.
Ping Sun, Chen Xu
doaj +1 more source
Distribution of the combinatorial multisets component vectors
Lietuvos Matematikos Rinkinys, 2012 We explore a class of random combinatorial structures called weighted multisets. Their components are taken from an initial set satisfying general boundedness conditions posed on the number of elements with a given weight.
Eugenijus Manstavičius +1 more
doaj +1 more source
A New Triangular Probability Model: A Combinatorial Modification of Probability Distributions
African Journal of Mathematics and Statistics StudiesThe paper projects innovating means to probability modeling using integration method and the concept of normalization. It brings to light a probability distribution obtained by combining a probability density function of a distribution and a cumulative distribution function of another continuous probability model, to produce a triangular trend and a ...
E. K. Guobadia +3 more
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The probability of nontrivial common knowledge [PDF]
We study the probability that two or more agents can attain common knowledge of nontrivial events when the size of the state space grows large. We adopt the standard epistemic model where the knowledge of an agent is represented by a partition of the ...
Marco LiCalzi, Andrea Collevecchio
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