Results 91 to 100 of about 5,770,503 (368)

Interventions for neurocognitive dysfunction [PDF]

, 2017
Purpose of review: To evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last three years. Recent findings: Optimal anti-retroviral therapy (ART) poses
Brew, B, Ellero, J, Lubomski, M
core   +2 more sources

First Year of Israeli Newborn Screening for Severe Combined Immunodeficiency—Clinical Achievements and Insights

Frontiers in Immunology, 2017
Severe combined immunodeficiency (SCID), the most severe form of T cell immunodeficiency, is detectable through quantification of T cell receptor excision circles (TRECs) in dried blood spots obtained at birth.
E. Rechavi, A. Lev, A. Simon, T. Stauber, Suha Daas, T. Saraf-Levy, A. Broides, A. Nahum, Nufar Marcus, Suhair Hanna, P. Stepensky, O. Toker, I. Dalal, Amos Etzioni, S. Almashanu, R. Somech   +15 more
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Water dispersible microbicidal cellulose acetate phthalate film [PDF]

, 2003
BACKGROUND: Cellulose acetate phthalate (CAP) has been used for several decades in the pharmaceutical industry for enteric film coating of oral tablets and capsules.
A Robert Neurath, A Stone, AC Gerbase, AJ Nahmias, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AV Kabanov, B Kovacs, C Coggins, CV Uglea, D Quintanar-Guerrero, DL Jones, DS Jones, G Green, G Ramjee, GN Milligan, H Arwidsson, H Chakraborty, H Ibrahim, H.L.,Jr. Martin, IJ Rosenstein, J Liao, JA Rottingen, JM Mann, JR Dyer, K Stiasny, KA Gates, KH Manson, KR Tambweker, L Van Damme, M Over, M Ratterree, MK Stafford, Nathan Strick, P Sakellariou, PL Perine, R Duncan, R Rustomjee, RE Roddy, RJ Harwood, RN Fichorova, RN Fichorova, SD Holmberg, SJ Reynolds, SR Goskonda, T Gyotoku, T Kawamura, T Kietzke, T Vemba, V Baeyens, V Rosilio, Yun-Yao Li   +57 more
core   +2 more sources

Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID)

Frontiers in Pediatrics, 2019
Severe Combined Immunodeficiencies (SCID) are a heterogeneous group of monogenetic diseases. We describe the typical clinical presentation of patients with SCID as well as basic principles in diagnosis and therapy by hematopoietic stem cell ...
E. Haddad, M. Hoenig
semanticscholar   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Detecting Mutations in the Mycobacterium tuberculosis Pyrazinamidase Gene pncA to Improve Infection Control and Decrease Drug Resistance Rates in Human Immunodeficiency Virus Coinfection. [PDF]

, 2016
Hospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB.
Bangsberg, Butler, Campos, Carlton A. Evans, Caviedes, Daniela E. Kirwan, David A. J. Moore, Dooley, Eduardo Ticona, Escombe, Escombe, Evans, Franzblau, Hannan, Hu, Huang, Iwamoto, Jon S. Friedland, Jorge Coronel, Kawai, Lilia Z. Cabrera, Louis Grandjean, Luz Caviedes, Luz Huaroto, Matthew Z. Dudley, Mirko Zimic, Mitchison, Moore, Moore, Patricia Sheen, Raviglione, Richard Rodriguez, Robert H. Gilman, Scorpio, Sheen, Sheen, Sheen, Steele, Stricof, Víctor Chávez-Pérez, Wells, Willingham   +41 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Loss of human ICOSL results in combined immunodeficiency

Journal of Experimental Medicine, 2018
Primary immunodeficiencies represent naturally occurring experimental models to decipher human immunobiology. We report a patient with combined immunodeficiency, marked by recurrent respiratory tract and DNA-based viral infections, hypogammaglobulinemia,
Lucie Roussel, Marija Landekic, M. Golizeh, C. Gavino, Ming-Chao Zhong, Jun Chen, D. Faubert, A. Blanchet-Cohen, L. Dansereau, Marc A. Parent, Sonia Marin, J. Luo, Catherine Le, Brinley R Ford, M. Langelier, Irah L. King, M. Divangahi, W. Foulkes, A. Veillette, D. Vinh   +19 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source