Results 151 to 160 of about 5,770,503 (368)

Case Report: Characterization of a RAC2 R68W homozygous activating mutation causing combined immune deficiency

Frontiers in Immunology
RAC2-related immunodeficiency is a rare inborn error of immunity with a broad clinical spectrum ranging from neonatal severe combined immunodeficiency to atypical combined immunodeficiency diagnosed later in life.
Aléhandra Desjardins, Aléhandra Desjardins, Louis Marois, Louis Marois, Ágnes Donkó, Guilhem Cros, Guilhem Cros, Marc-Antoine Bédard, Marie-Lorna Paul, Amy P. Hsu, Emma Darbinian, Géraldine Gosse, Thomas L. Leto, Hugo Chapdelaine, Hugo Chapdelaine, Chantal Massé, Isabel Fernandez, Fabien Touzot, Fabien Touzot, Herawaty Sebajang, Emilia Liana Falcone, Emilia Liana Falcone, Emilia Liana Falcone, Emilia Liana Falcone   +23 more
doaj   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Omenn syndrome: a case report and review of literature

Dermatologica Sinica, 2011
Exfoliative dermatitis or erythroderma in infancy is rare. Clinicians need to be alert to the possible diagnosis of Omenn syndrome (OS), a rare form of combined immunodeficiency in infants presenting with recurrent infections, erythroderma ...
Chia-Chi Hsu, Julia Yu-Yun Lee, Sheau-Chiou Chao   +2 more
doaj   +1 more source

Combined immunodeficiency and impaired PI3K signaling in a patient with biallelic LCP2 variants [PDF]

, 2023
Emily S.J. Edwards, Samar Ojaimi, James Ngui, Go Hun Seo, Jihye Kim, Sanjeev Chunilal, Deborah Yablonski, Robyn E. O’Hehir, Menno C. van Zelm   +8 more
openalex   +1 more source

Combined Immunodeficiency in Patients With Trichohepatoenteric Syndrome

Frontiers in Immunology, 2018
The syndromic diarrhea/trichohepatoenteric syndrome (SD/THE) is a rare and multi-system genetic disorder caused by mutation in SKIV2L or in TTC37, two genes encoding subunits of the putative human SKI complex involved in RNA degradation.
F. Vely, V. Barlogis, E. Marinier, Marie-Edith Coste, B. Dubern, E. Dugelay, J. Lemale, C. Martinez-Vinson, N. Peretti, Ariane Perry, P. Bourgeois, C. Badens, O. Goulet, J. Hugot, C. Farnarier, A. Fabre   +15 more
semanticscholar   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

Paradoxical Enhancement of Tumor Growth in Mice with Severe Combined Immunodeficiency which Produce a Human Immunoglobulin G Reactive against Tumor Cells [PDF]

, 1994
Toshiharu Furukawa, Masahiko Watanabe, Tetsuro Kubota, Masaki Kitajima   +3 more
openalex   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

An Atypical Severe Combined Immunodeficiency (SCID) Case Diagnosis Complicated by Alternative Care in the Era of Newborn Screening (NBS) for SCID [PDF]

, 2017
Taylor Alberdi, Johana B Castro-Wagner, Bhumika Patel, Sonia Joychan, David Hobbs Lindsey, Frederico R. Laham, Krisztián Csomós, Boglárka Ujházi, Carla Duff, Jessica Trotter, Jack Bleesing, Attila Kumánovics, Yenhui Chang, Jamie H. Hale, Panida Sriaroon, Greg Hale, Benjamin Oshrine, Luigi D. Notarangelo, Roshini S. Abraham, Anne Marie Comeau, Aleksandra Petrovič, Jennifer W. Leiding, Jolán E. Walter   +22 more
openalex   +1 more source