Results 221 to 230 of about 5,770,503 (368)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

A novel <i>de novo IL2RG</i> nonsense mutation in a pediatric patient with X-linked severe combined immunodeficiency. [PDF]

Front Genet
Wang L, Ren A, He Y, Wang L, Wang S, Xie X, Tan M, Chen Y, Huang P, Du Z.   +9 more
europepmc   +1 more source

T−B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3ζ subunit of the T-cell antigen receptor complex

, 2006
Joseph L. Roberts, Jens Peter H. Lauritsen, Myriah Cooney, Roberta Parrott, Elisa O. Sajaroff, Chan M. Win, Michael D. Keller, Jeffery H. Carpenter, Juan Carabaña, Michael S. Krangel, Marcella Sarzotti, Xiao‐Ping Zhong, David L. Wiest, Rebecca H. Buckley   +13 more
openalex   +2 more sources

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency.

New England Journal of Medicine, 2003
S. Hacein-Bey-Abina, C. von Kalle, M. Schmidt, F. Le Deist, N. Wulffraat, Elisabeth McIntyre, I. Radford, J. Villeval, C. Fraser, M. Cavazzana‐Calvo, A. Fischer   +10 more
semanticscholar   +1 more source

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source

Late-Onset Combined Immunodeficiency presenting with Progressive Multifocal Leukoencephalopathy and associated Immune Reconstitution Inflammatory Syndrome. [PDF]

Infez Med
Mezzadri L, Borghesi ML, Comoli P, Pozzi MR, Lapadula G, Rossi M, Bonfanti P.   +6 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Loss of MALT1 Function in a Patient With Combined Immunodeficiency: a Novel Pathogenic Variant and Immunological Insights. [PDF]

J Clin Immunol
Tian Z, Chen R, Jia Y, Jiang J, Dai R, An Y, Tang X, Zhao X, Zhou L.   +8 more
europepmc   +1 more source

A rare case of pulmonary disease combining alpha-1-antitrypsin deficiency and common variable immunodeficiency

, 2020
Cláudia S. Sousa, V. Teixeira, Vítor Magno Pereira, Rafaela Brito Bezerra Pinheiro, Susana Seixas, Natália Martins   +5 more
openalex   +1 more source

Thirty Years of Mentoring by “Bob Chan” of Young Japanese Surgeons to Become Scientists: An Adventure of Love

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Over the past three decades, we have mentored a generation of young Japanese surgeons, guiding them to become internationally recognized surgeon‐scientists. Through a unique collaboration between Japanese academic institutions and our laboratories at AntiCancer Inc.
Robert M. Hoffman, Kentaro Miyake, Itaru Endo   +2 more
wiley   +1 more source