Results 111 to 120 of about 659,807 (312)
Static and yawed-rolling mechanical properties of two type 7 aircraft tires [PDF]
Selected mechanical properties of 18 x 5.5 and 49 x 17 size, type 7 aircraft tires were evaluated. The tires were subjected to pure vertical loads and to combined vertical and lateral loads under both static and rolling conditions.
Mccarty, J. L. +2 more
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Load-case and -combination database
, 2022 The loading database is part of the pipeline analysis and monitoring system that will be used for nuclear power plant piping systems and connected equipment at two Finnish nuclear power plants. These plants are situated in Olkiluoto and operated by Teollisuuden Voima Oy (TVO).
Raiko, Heikki +3 more
openaire +3 more sources
Zhongguo Jianchuan YanjiuObjectiveIn order to find a numerical simulation method that can simulate the combined effects of multi-damage loads under cabin internal explosion, while considering both simulation accuracy and efficiency, this paper proposes two high-efficiency ...
Zhenhao WU +2 more
doaj +1 more source
Computer-aided methods for analysis and synthesis of supersonic cruise aircraft structures [PDF]
Computer-aided methods are reviewed which are being developed by Langley Research Center in-house work and by related grants and contracts. Synthesis methods to size structural members to meet strength and stiffness (flutter) requirements are emphasized ...
Giles, G. L.
core +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Verifying a Glass Pane Under Combined In-Plane Compression and Out-of-Plane Lateral Loads
Challenging Glass Conference ProceedingsUsing glass elements as designated members of the structural design of buildings does not only require conscientious planning of structural redundancies, but also proof of safety for single components.
Philipp Kießlich +2 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Preparation for Testing a Multi-Bay Box Subjected to Combined Loads [PDF]
The COmbined Loads Test System (COLTS) facility at NASA Langley Research Center provides a test capability to help develop validated structures technologies.
Jegley, Dawn, Rouse, Marshall
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source