Results 141 to 150 of about 659,807 (312)
Combined bearing and bypass loading on a graphite/epoxy laminate [PDF]
A combined experimental and analytical study was conducted to determine the behavior of a graphite/epoxy laminate subjected to combined bearing and bypass loading.
Crews, J. H., Jr., Naik, R. A.
core +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Performance of computer-optimized tapered-roller bearings to 2.4 million DN [PDF]
The performance of 120.65 mm bore high speed design tapered roller bearings was investigated at shaft speeds to 20,000 rpm under combined thrust and radial load. The test bearing design was computer optimized for high speed operation.
Parker, R. J. +2 more
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Water Quality Sampling, Analysis and Annual Load Determinations for the Illinois River at Arkansas Highway 59 Bridge, 2008 [PDF]
, 2009 The Arkansas Water Resources Center monitored water quality at the Illinois River at the Arkansas Highway 59 Bridge, just upstream from the Arkansas-Oklahoma state border during base flow and storm events from July 1, 2008 through June 30, 2009.
Cash, L.W., Haggard, B.E., Massey, L.B.
core +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Probabilistic assessment of space trusses subjected to combined mechanical and thermal loads [PDF]
A three-bay, space, cantilever truss is probabilistically evaluated to quantify the range of uncertainties of buckling loads and member forces due to nonuniform thermal loads, applied loads and moments (mechanical loads), and combination of both.
Chamis, Christos C., Pai, Shantaram S.
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Minimum-mass design of filamentary composite panels under combined loads: Design procedure based on a rigorous buckling analysis [PDF]
A procedure is presented for designing uniaxially stiffened panels made of composite material and subjected to combined inplane loads. The procedure uses a rigorous buckling analysis and nonlinear mathematical programing techniques.
Agranoff, N. +2 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source