Results 51 to 60 of about 279,274 (345)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The factors that influence adherence of pregnant women with HIV/AIDS to anti-retroviral therapy [PDF]

Revista Brasileira em Promoção da Saúde, 2011
Objective: To learn the experiences of pregnant women with HIV/AIDS in relation to adherence to antiretroviral therapy in two public hospitals of reference for HIV/AIDS in Fortaleza-CE, Brazil.
Valéria Lima de Barros, Maria Alix Leite Araújo, Maria Natália Araújo de Alcântara, Marilene Alves Oliveira Guanabara, Simone Paes de Melo, Suzyanne da Silva Sobreira Guedes   +5 more
doaj  

Primary endocrine therapy of locally advanced breast cancer patients [PDF]

Archive of Oncology, 2003
Primary endocrine therapy has been traditionally reserved for elderly and unfit locally advanced breast cancer patients (LABC patients). In this group, the primary endocrine therapy could not be adequately compared to primary chemotherapy.
Nešković-Konstantinović Zora B.
doaj   +1 more source

Evaluation of Xpert® MTB/RIF and ustar easyNAT™ TB IAD for diagnosis of tuberculous lymphadenitis of children in Tanzania : a prospective descriptive study [PDF]

, 2016
Fine needle aspiration biopsy has become a standard approach for diagnosis of peripheral tuberculous lymphadenitis. The aim of this study was to compare the performance of Xpert MTB/RIF and Ustar EasyNAT TB IAD nucleic acid amplification assays, against ...
AT Cruz, CA Wright, CA Wright, CA Wright, CC Anunobi, CC Boehme, CJL Murray, CM Denkinger, CM Denkinger, CM Perez-Velez, D Hillemann, E Penz, Edward Masika, ES Cibas, F Ardito, FA Mhimbira, Hans-Peter Beck, Hassan Chande, J Ayugi, J Cohen, JA Seddon, JB Reitsma, Klaus Reither, L Coetzee, Levan Jugheli, M Pai, Maira Bholla, Mohamed Sasamalo, Neema Kapalata, PJ Dodd, R Fang, RR Kazwala, S Chakravorty, SGM Mfinanga, SH Siddiqi, SM Newton, Tracy R. Glass, Ustar Biotechnologies, World Health Organization, X Ou   +39 more
core   +3 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Prognostic Significance of the Lymph Node Ratio Regarding Recurrence and Survival in Rectal Cancer Patients Treated with Postoperative Chemoradiotherapy

Gut and Liver, 2012
Background/AimsTo evaluate the prognostic impact of the lymph node ratio (LNR: the ratio of positive lymph nodes to the total number of lymph nodes examined) on disease recurrence and survival among rectal cancer patients who received curative surgery ...
doaj   +1 more source

Combined Modality Therapy of Gemcitabine and Radiation

The Oncologist, 2005
Abstract Learning Objectives After completing this course, the reader will be able to: List the advantages of combination chemotherapy and radiotherapy. Explain the rationale for doing in vitro research in the radiochemotherapy field.
Pauwels, Bea, Korst, Anne Elisabeth Cornelia, Lardon, Filip, Vermorken, Jan Baptist   +3 more
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Optical Coherence Tomographic Angiography Imaging in Age-Related Macular Degeneration. [PDF]

, 2017
Optical coherence tomographic angiography (OCTA) is emerging as a rapid, noninvasive imaging modality that can provide detailed structural and flow information on retinal and choroidal vasculature.
Desai, Ria, Fawzi, Amani, Gill, Manjot, Ma, Jeffrey, Nesper, Peter, Skondra, Dimitra   +5 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source