Results 61 to 70 of about 284,364 (303)

Combined Modality Therapies for High-Risk Prostate Cancer: Narrative Review of Current Understanding and New Directions. [PDF]

, 2019
Despite the many prospective randomized trials that have been available in the past decade regarding the optimization of radiation, hormonal, and surgical therapies for high-risk prostate cancer (PCa), many questions remain.
Chen, Victor E., Den, Robert B., Greenberger, Benjamin A.   +2 more
core   +1 more source

Comparing the effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in the treatment of depression : a systematic review and meta-analysis [PDF]

, 2014
Electroconvulsive therapy (ECT) is the longest standing psychiatric treatment available and has unequivocal benefit in severe depression. However this treatment comes with a number of side effects such as memory impairment.
Micallef-Trigona, Beppe
core   +4 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Multimodal analgesia versus patient-controlled analgesia in the management of acute postoperative spinal pain: systematic review and meta-analysis

BrJP
BACKGROUND AND OBJECTIVES: Spine diseases have a high annual prevalence and are the main causes of years lived with disability and chronic pain. Among the postoperative analgesic control options, patient-controlled analgesia (PCA) and multimodal ...
Lucas de Melo Castro Deligne, Guilherme Baldez Pinheiro, Marcelo de Oliveira Peres, André Moreira Castilho   +3 more
doaj   +1 more source

Neoadjuvant Concurrent Chemoradiation in Locally Advanced Adenocarcinoma of Gastroesophageal Junction & Proximal Stomach (A Single Arm Study): Our Experience From Single Institute From Kashmir Valley

JK Science, 2023
Introduction: The aim of this study was to investigate the efficacy and safety of using a neo-adjuvant concomitant chemoradiation therapy to treat potentially resectable adenocarcinoma of the gastroesophageal junction & proximal stomach.
Murtaza Shafi, Mohammad Maqbool Lone, Mushtaq Ahmad Sofi, Khursheed Alam Wani, Gul Mohammad Bhat, Tavseef Ahmad Tali, Mansoora Akhter   +6 more
doaj  

Psychosocial treatments for negative symptoms in schizophrenia: current practices and future directions. [PDF]

, 2013
Schizophrenia can be a chronic and debilitating psychiatric disorder. Though advancements have been made in the psychosocial treatment of some symptoms of schizophrenia, people with schizophrenia often continue to experience some level of symptoms ...
Caponigro, Janelle M, Elis, Ori, Kring, Ann M   +2 more
core  

Monitoring Breast Cancer Response to Neoadjuvant Chemotherapy Using Ultrasound Strain Elastography [PDF]

, 2019
© 2019 The Authors Strain elastography was used to monitor response to neoadjuvant chemotherapy (NAC) in 92 patients with biopsy-proven, locally advanced breast cancer. Strain elastography data were collected before, during, and after NAC.
Curpen, B., Czarnota, G., El Kaffas, A., Faltyn, J., Fernandes, J., Gandhi, S., Hadizad, F., Koven, A., Sadeghi-Naini, A., Sannachi, L., Tran, William, Watkins, E., Wright, F.   +12 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Best evidence rehabilitation for chronic pain, part 3 : low back pain [PDF]

, 2019
Chronic Low Back Pain (CLBP) is a major and highly prevalent health problem. Given the high number of papers available, clinicians might be overwhelmed by the evidence on CLBP management.
Bilterys, Thomas, Bogaert, Wouter, Coppieters, Iris, Huysmans, EVa, Ickmans, Kelly, Malfliet, Anneleen, Nijs, Jo, Rheel, Emma, Wilgen, Paul, Willaert, Ward   +9 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source