Results 121 to 130 of about 209,758 (346)

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp   +6 more
wiley   +1 more source

Combined oral contraceptives and thromboembolism [PDF]

open access: yesBMJ, 1995
EDITOR,--It is understandable that last week's BMJ should devote considerable space to the Committee on Safety of Medicines' recent advice1 on combined oral contraceptives and venous thromboembolism.2 3 4 5 6 I doubt, however, whether your readers will be enlightened by some of the views expressed in it.
openaire   +1 more source

Anthropological Differences between Contraception and Natural Family Planning [PDF]

open access: yes, 2000
Almost twenty years ago, Pope John Paul II in his apostolic exhortation Familiaris Consortio called on scholars to study the anthropological and moral differences between the recourse to the natural rhythms of a woman’s menstrual cycle (i.e., natural ...
Fehring, Richard, Kurz, William
core   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić   +7 more
wiley   +1 more source

Effect of combined oral contraceptives on orthodontic tooth movement in a female rat model

open access: yesAustralasian Orthodontic Journal, 2019
To investigate the effect of combined oral contraceptives (COC) on orthodontic tooth movement (OTM) and periodontal remodelling in a female rat model.
Yu Jinghong   +7 more
doaj   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh   +5 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

open access: yes, 2022
Hepatology, EarlyView.
Robert J. Fontana   +6 more
wiley   +1 more source

Reproductive Wastage in Recurrent Partial Hydatidiform Mole: A Clinical Dilemma. [PDF]

open access: yes, 2013
Recurrent partial Hydatidiform mole is an extremely rare clinical entity which represent a part of the gestational trophoblatic neoplasia spectrum. Since the first case was reported by Honore.
Ashmita, D   +3 more
core  

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert   +6 more
wiley   +1 more source

Proximate Determinants of Women's Use of Birth Control Methods in Ota,Ogun State [PDF]

open access: yes, 2013
Fertility regulation and pregnancy prevention are among the major health challenges of the 21st century in sub-Saharan Africa, especially in Nigeria. Contraception has been identified as an effective means of combating the problem of unwanted pregnancy
Abimbola, O. H.   +3 more
core  

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