Results 121 to 130 of about 3,821,748 (294)

When rare conditions collide: plantar vein thrombosis in hereditary spherocytosis

Journal of the Foot & Ankle
Plantar heel pain is a common orthopedic complaint, but less frequent etiologies like plantar vein thrombosis (PVT) are often overlooked. We present the case of a 27-year-old female with a history of hereditary spherocytosis who developed left plantar ...
Budak Akman, Behic Celik, Betul Uzunoglu
doaj   +3 more sources

Postabortal rehabilitation – aspects of the problem: possibilities of combined oral contraceptives

Гинекология, 2013
The article presents modern concepts of pharmacological possibilities to use combined oral contraceptives for prevention of various postabortal complications, rational approaches of their use in female patients in postabortal period.
M B Khamoshina, I S Savelyeva, E A Zorina, M S Tulupova, T N Zulumyan   +4 more
doaj  

Exposure‐Response Analyses of Datopotamab Deruxtecan (Dato‐DXd), a TROP2‐Directed Antibody‐Drug Conjugate, in Advanced Non‐small Cell Lung Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong, Anna M. Mc Laughlin, Yuzhuo Pan, Sofia Friberg Hietala, Sophie Peigné, Michael Chargualaf, Zoey Tang, Diansong Zhou, Naoyuki Tajima, Malaz Abutarif, Tushar Garimella   +10 more
wiley   +1 more source

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, EarlyView.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

Evaluating Vaginal Microbiome Effects on Antiretroviral Exposure in the Female Genital Tract Using Pharmacometric and Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Antiretroviral pre‐exposure prophylaxis (PrEP) is less effective in women than expected, partly because drug exposure within the female genital tract is variable and may be influenced by the vaginal microbiome. We developed an integrated pharmacometrics and machine learning framework to evaluate associations between vaginal microbiome composition and ...
Diqin Yan, Lindsey B. Collins, Christopher Staley, Flavia Kiweewa Matovu, Pamala Jacobson, Melanie Nicol, Shen Cheng   +6 more
wiley   +1 more source

Cross‐sectional and longitudinal metabolomics‐based profiles associated with oral contraceptive and progestin‐only pill use: A Finnish population‐based study

Acta Obstetricia et Gynecologica Scandinavica
Introduction The use of combined oral contraceptives (COCs), but not of progestin‐only pills (POPs) is associated with an increased risk of cardiovascular events.
Elena Toffol, Jari Haukka, Pekka Jousilahti, Lara Lehtoranta, Anni Joensuu, Timo Partonen, Iris Erlund, Oskari Heikinheimo   +7 more
doaj   +1 more source

Classification of combined oral contraceptives according to the type of progestogen.

, 2014
Classification of combined oral contraceptives according to the type of progestogen.
Aurore Tricotel (359607), Cédric Collin (585517), Mahmoud Zureik (585518), Fanny Raguideau (585516)   +3 more
core   +1 more source

Medication Use During Breastfeeding—An Understudied Population: A Five‐Year Experience in the Pharmacovigilance Center of Lyon

Clinical Pharmacology &Therapeutics, EarlyView.
Medication use during breastfeeding is common, yet data on drug transfer into breast milk and infant exposure remain limited. This study describes real‐world requests concerning medication compatibility with breastfeeding managed by the Lyon pharmacovigilance center over five years.
Blandine Bertin, Aurore Gouraud, Anthony Facile, Fanny Ledys, Sabrina Pierre, Véronique Pizzoglio, Thierry Vial, Marine Auffret, Marina Atzenhoffer   +8 more
wiley   +1 more source

The knowledge of combined oral contraceptives and errors in their use among young women of Vilnius city and district. [PDF]

, 2019
A voluntarily anonymous online survey of young women aged 15–35 years was carried out to evaluate and compare the knowledge of efficient and continuous use, the factors affecting the effectiveness of combined oral contraceptives and knowledge of ...
Kovalevska, Mariola
core  

Intra‐Individual Variability of Blood and Urinary Steroid Markers and the Response to Codeine Intake in Healthy Men and Women

Drug Testing and Analysis, EarlyView.
Short‐term codeine administration (1–3 days) caused individual alterations in Athlete Biological Passport steroid markers, including elevated urinary T/E ratios and decreased serum testosterone concentrations below individual thresholds, despite no significant changes at the group level.
Alexander Andersson, Basam Yousif, Anton Pohanka, Annica Börjesson, Mikael Lehtihet, Lena Ekström   +5 more
wiley   +1 more source