Results 61 to 70 of about 3,553,850 (264)

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

High prevalence of PROP1 gene mutations in Hungarian patients with childhood-onset combined anterior pituitary hormone deficiency

, 2017
Combined pituitary hormone deficiency is characterized by the impaired production of pituitary hormones, commonly including growth hormone. The pathomechanism of the childhood-onset form of this disorder may involve germline mutations of genes encoding ...
Rácz, Károly, Bertalan R, Halász, Zita, Sallai, Ágnes, Kovacs L, Patócs, Attila Balázs, Tombol Z, Fekete, György, Tőke, Judit, Hosszú, Éva, Sólyom, János, Muzsnai, Ágota   +11 more
core   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

Congenital Hypopituitarism due to POU1F1 Gene Mutation

Journal of the Formosan Medical Association, 2011
POU1F1 (Pit-1; Gene ID 5449) is an anterior pituitary transcriptional factor, and POU1F1 mutation is known to cause anterior pituitary hypoplasia, growth hormone and prolactin deficiency and various degree of hypothyroidism.
Ni-Chung Lee, Wen-Yu Tsai, Shinn-Forng Peng, Yi-Ching Tung, Yin-Hsiu Chien, Wuh-Liang Hwu   +5 more
doaj   +1 more source

Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg-->Cys at codon 120 (R120C). [PDF]

, 1998
As pituitary function depends on the integrity of the hypothalamic-pituitary axis, any defect in the development and organogenesis of this gland may account for a form of combined pituitary hormone deficiency (CPHD).
Wu, W., Mullis, P. E., Deladoey, J., Flück, Christa, Eblé, A., Marti, U., Rutishauser, K.   +6 more
core   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

Post-traumatic pituitary stalk transection syndrome (PSTS) expeditiously manifested after a fall from a height combined with acute traumatic spinal cord injury: a rare case report with review of literature

Endocrine Journal
Post-traumatic pituitary stalk transection syndrome (PSTS) is an extremely rare cause of combined pituitary hormone deficiency (CPHD), affecting approximately 9 per 100,000 cases of traumatic brain injury.
Yohei Ishiki, Atsuko Tamaki, Ken-ichiro Honma, Ken Yonaha, Takamitsu Yabiku, Taiki Teruya, Moriyuki Uehara, Yoshiro Nakayama, Rei Chinen, Tsugumi Uema, Sawako Nakachi, Shiki Okamoto, Hiroaki Masuzaki   +12 more
doaj   +1 more source

Panhypopituitarism in adults: modern views and case analysis

Архивъ внутренней медицины, 2019
The article is devoted to the problem of panhypopituitarism, the diagnosis of which presents certain difficulties in connection with the combined lesion of several peripheral endocrine glands.
L. M. Farkhutdinova
doaj   +1 more source