Results 81 to 90 of about 3,553,850 (264)

Growth hormone deficiency with advanced bone age: phenotypic interaction between GHRH receptor and CYP21A2 mutations diagnosed by sanger and whole exome sequencing

Archives of Endocrinology and Metabolism
SUMMARY Isolated growth hormone deficiency (IGHD) is the most common pituitary hormone deficiency and, clinically, patients have delayed bone age.
Fernanda A. Correa, Marcela M. França, Qing Fang, Qianyi Ma, Tania A. Bachega, Andresa Rodrigues, Bilge A. Ozel, Jun Z. Li, Berenice B. Mendonca, Alexander A. L. Jorge, Luciani R. Carvalho, Sally A. Camper, Ivo J. P Arnhold   +12 more
doaj   +1 more source

Growth hormone deficiency with late-onset hypothalamic hypoadrenocorticism associated with respiratory and renal dysfunction: a case report

BMC Endocrine Disorders, 2020
Background The prevalence of childhood-onset growth hormone (GH) deficiency (GHD) is estimated to be approximately 1 in 5000 or more, with the cause unknown in most cases (idiopathic isolated GHD).
Nami Kojima, Nobuyuki Koriyama, Akinori Tokito, Kazuma Ogiso, Koshi Kusumoto, Satoshi Kubo, Yoshihiko Nishio   +6 more
doaj   +1 more source

Combined Pituitary Hormone Deficiency Caused by a Synonymous HESX1 Gene Mutation [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2019
Mutations in the HESX1 gene can give rise to complex phenotypes that involve variable pituitary hormone deficiencies and other developmental defects.A 14-year-old boy presented with short stature and delayed puberty and received a diagnosis of GH deficiency, central hypothyroidism, hypogonadotropic hypogonadism, and secondary adrenal insufficiency.
Eduarda Coutinho, Carla Maria Brandão, Manuel Carlos Lemos   +2 more
openaire   +2 more sources

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Novel mechanism of pituitary hormone deficiency: genetic variants shift splicing to produce a dominant negative transcription factor isoform

, 2021
International audienceRecent studies have shown a novel mechanism of combined pituitary hormone deficiency associated with mutations in POU1F1 , altering the balance of alternative-splicing, which results in over-expression of the beta isoform of POU1F1.
Brue, Thierry, Camper, Sally, Sally A Camper, Thierry Brue   +3 more
core   +1 more source

Effect of Cyclic Heat Exposure on the Growth Performance and Metabolism of Broilers Fed Palm Kernel Meal

Animal Research and One Health, EarlyView.
The aim of our study is to evaluate the interaction between HS and the incorporation of PKM in broiler chicken diets, as well as its effect on growth performance and metabolism. Based on the results obtained, PKM supplementation failed to mitigate the adverse effects of heat stress in broiler chickens. ABSTRACT The aim of this study was to evaluate the
Ahmed Mijiyawa, Elham Ghashghaei, Okasha Hamada, Huimin Wang, Lijing Sun, Yendouhamtchié Nadiedjoa, Dan Wang, Zhengkai Yue, Clarice Maa Maa Temhoul, Maxwell Ansong Okai, Muhammad Faisal Riaz, Felix Kwame Amevor, Wéré Pitala, Hai Lin   +13 more
wiley   +1 more source

Retrospective, multicentre evaluation of central congenital hypothyroidism in the UK

European Thyroid Journal
Objective: Central congenital hypothyroidism (incidence ∼1:13,000) occurs in isolation (40% cases) or with additional pituitary hormone deficiencies. T4 ± TSH-based neonatal screening detects central congenital hypothyroidism within the first two weeks ...
Catherine Peters, Claire Wood, James M Law, Chloe Stevens, Fatemah Alhusaini, Darla Rigby, Hannah Hornby, Tim Cheetham, Nadia Schoenmakers   +8 more
doaj   +1 more source

De morseir syndrome presenting as ambiguous genitalia

Indian Journal of Endocrinology and Metabolism, 2012
Background: A 10-year-old boy presented with genital ambiguity, poor linear growth, and delayed milestones. The aim and to highlight that although rare but congenital, hypogonadotropic hypogonadism may rarely present as ambiguity.
Anubhav Thukral, S Chitra, Partho P Chakraborty, Ajitesh Roy, Soumik Goswami, Rana Bhattacharjee, Deep Dutta, Indira Maisnam, Sujoy Ghosh, Satinath Mukherjee, Subhankar Chowdhury   +10 more
doaj   +1 more source

Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope

Animal Research and One Health, EarlyView.
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad, Hubdar Ali Kolachi, Jesse Oluwaseun Ayantoye, Xiaomeng Zhang, Muhammad Usman Mehmood, Rajilan Hilali Shanga, Pengcheng Wan, Xueming Zhao   +7 more
wiley   +1 more source

A Pedigree With LHX4 and SOX3 Gene Variants Resulting in Gonadal Dysplasia

Clinical Case Reports
Pituitary stalk interruption syndrome is a disease with multiple hormone deficiencies caused by pituitary stalk interruption. Identification of the pathogenic gene variant is helpful for early diagnosis.
Zhaoyang Ji, Wenyuan Duan, Jianbo Wu, Mengting Dai, Ping Chen, Jialu Luo, Mingzhi Xu   +6 more
doaj   +1 more source