Results 171 to 180 of about 850,969 (288)

Oral Delivery of Bioencapsulated CTB‐Pro‐IGF‐1 Enhances Bone Regeneration in a Pre‐Clinical Rat Model of Jaw Osteoradionecrosis

Oral Diseases, EarlyView.
ABSTRACT Objective Head and neck cancer radiotherapy can lead to jaw osteoradionecrosis (ORN). There is currently no definitive treatment for ORN. The efficacy of a novel orally delivered aglycosylated IGF‐1 with an E‐peptide (CTB‐Pro‐IGF‐1), bioencapsulated in plant cells, was evaluated as therapy for jaw ORN in rats. Materials and Methods Rat jaw ORN
Sunday O. Akintoye, Arularasan Anbinselvam, Prasath Jeyaraman, Uddhab Karki, Geetanjali Wakade, Henry Daniell   +5 more
wiley   +1 more source

Double-stranded sperm DNA fragmentation measured with neutral comet assay as a predictor of IVF outcomes: evidence from three European clinics in a multi-centred prospective study. [PDF]

Hum Reprod
Humaidan P, Povlsen BB, Drakeley AJ, Jensen MB, Gabrielsen AV, McDowell SH, Moore L, Ledgerwood CJ, Rae L, Sloan A, Lawlor M, Poots L, Bailie E, Lunt RL, Newton E, Gregoire RC, Moore TCB, Esteves SC.   +17 more
europepmc   +1 more source

A High-Throughput Comet Assay Approach for Assessing Cellular DNA Damage. [PDF]

J Vis Exp, 2022
Ji Y, Karbaschi M, Abdulwahed A, Quinete NS, Evans MD, Cooke MS.   +5 more
europepmc   +1 more source

RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation

Photochemistry and Photobiology, EarlyView.
UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan, Angitha Nair, M. Alexandra Carpenter, Michael G. Kemp   +3 more
wiley   +1 more source

Impact of cryopreservation on DNA damage in Acer platanoides L. seeds evaluated by the comet assay. [PDF]

Sci Rep
Plitta-Michalak BP, Ramos AA, Trusiak M, Ratajczak E, Michalak M.   +4 more
europepmc   +1 more source

Evaluating nanobiomaterial-induced DNA strand breaks using the alkaline comet assay. [PDF]

Drug Deliv Transl Res, 2022
Tutty MA, Vella G, Vennemann A, Wiemann M, Prina-Mello A.   +4 more
europepmc   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Induction of Sperm DNA Fragmentation by Cryopreservation and In Vitro Incubation: Comparison of TUNEL, SCSA, SCD Test and COMET Assay. [PDF]

Int J Mol Sci
Calamai C, Tanturli M, Conti D, Leter G, Vignozzi L, Giovannelli L, Muratori M.   +6 more
europepmc   +1 more source

Cell survival after DNA damage in the comet assay. [PDF]

Arch Toxicol, 2021
Bankoglu EE, Schuele C, Stopper H.
europepmc   +1 more source

Definition and recommendations for trial methods for evaluating dentin hypersensitivity: A hybrid AI‐assisted scoping review and Delphi consensus process

Periodontology 2000, EarlyView.
Abstract Background Dentin hypersensitivity (DH) is a common yet inconsistently defined condition impacting oral health and quality of life. Variability in diagnostic criteria and trial methodologies has limited comparability of previous research. Objectives To map current definitions, diagnostic frameworks, and clinical trial methodologies in DH ...
Alexander J. Pollard, Tom J. Pollard, Anne‐Marie Glenny, Jan Clarkson, Tanya Walsh, Maria Davies, Thomas Sounack, Matthew Wright, Joon Seong, Joshua Twigg, Rupert Austin, Rossana Izzetti, Crystal Marruganti, Robert Newcombe, Rebecca Bullock, Nicola X. West   +15 more
wiley   +1 more source