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The In Vitro and In Vivo Comet Assays
2011The strategy for testing for genotoxicity covers three main areas, namely gene mutation, chromosome aberration or breakage (clastogenicity), and chromosome loss or gain (aneuploidy). The current generalized strategy consists of assays capable of detecting all of these endpoints using in vitro assays such as the Ames test for detecting gene mutations in
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The Comet Assay in Human Biomonitoring
Human biomonitoring studies aim to identify potential exposures to environmental, occupational, or lifestyle toxicants in human populations and are commonly used by public health decision-makers to predict disease risk. The Comet assay measures changes in genomic stability and is one of the most reliable biomarkers to indicate early biological effects,Mojgan, Najafzadeh +3 more
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Impact of the comet assay in radiobiology
Mutation Research/Reviews in Mutation Research, 2009Until the development of single cell gel electrophoresis methods in the 1980s, measurement of radiation-induced DNA strand breaks in individual cells was limited to detection of micronuclei or chromosome breaks that measured the combined effects of exposure and repair.
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Do cytotoxicity and cell death cause false positive results in the comet assay?
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2022Peter Møller +2 more
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The Comet assay for the evaluation of genotoxic impact in aquatic environments
Mutation Research - Reviews in Mutation Research, 2009B P Lyons, B P Lyons, Marco Nigro
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The comet assay as a tool for human biomonitoring studies: The ComNet Project
Mutation Research - Reviews in Mutation Research, 2014Andrew R. Collins +2 more
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