Results 231 to 240 of about 850,969 (288)
SIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin‐Modifying Complexes
Aging Cell, Volume 25, Issue 9, September 2026.SIRT1 binds the LINE‐1 5′‐UTR and recruits the heterochromatin modifiers Lamin B1 and KAP1 to maintain H3K9me3 levels, thereby suppressing LINE‐1 retrotransposition. SIRT1 deficiency enhances LINE‐1 transcription, leading to upregulation of senescence‐associated secretory phenotype factors, activation of the cGAS‐STING pathway, and consequent cellular ...
Xiaona Wang +8 more
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 9, September 2026.ABSTRACT Early clinical development of anticancer drugs traditionally focused on exploring candidate treatments in patients. For instance, due to their cytotoxic action, administration of chemotherapies to healthy volunteers (HVs) for evaluation of their pharmacokinetic profiles was not considered feasible nor ethical from a safety and tolerability ...
Aernout D. van Haarst +5 more
wiley +1 more source
Drug and Alcohol Review, Volume 45, Issue 6, September 2026.ABSTRACT Introduction Post‐traumatic stress disorder (PTSD) commonly co‐occurs with substance use disorders (SUD), yet few community‐based SUD programs incorporate evidence‐based trauma‐focused. Prolonged exposure (PE), including its massed format (M‐PE) with session frequency of 3–4 times per week, is a gold standard intervention for PTSD; however ...
Steven Curto +7 more
wiley +1 more source
Surgical management of recurrent oesophageal obstruction in a yearling Saddlebred filly
Equine Veterinary Education, Volume 38, Issue 9, Page e585-e590, September 2026.Summary This case report describes the diagnostic approach and surgical management of a yearling Saddlebred filly with recurrent oesophageal obstruction, likely caused by an acquired extraluminal oesophageal stricture. The filly initially presented with repeated episodes of oesophageal obstruction, which were resolved with sedation and nasogastric ...
K. M. Andrews +4 more
wiley +1 more source
DNS reparáció vizsgálatok emlőssejt tenyészeteken és Alzheimer-kóros betegek limfocitáin [PDF]
, 2003 Mórocz Mónika
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HIV Medicine, Volume 27, Issue 9, Page 1421-1433, September 2026.Abstract Objectives Increasing rates of HIV‐1 drug resistance (HIVDR) threaten the effectiveness of antiretroviral therapy (ART) programmes in sub‐Saharan Africa, particularly among children, adolescents and young adults, who face limited treatment options.
Dominic Rauschning +16 more
wiley +1 more source
The Comet assay in the evaluation of oxidative stress in patients with Parkinson’s disease
, 2007 COZZI, Renata +6 more
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Journal of Animal Breeding and Genetics, Volume 143, Issue 5, Page 613-624, September 2026.ABSTRACT Recent studies suggest that variations in milk yield during lactation can serve as a metric for assessing individual resilience, with minimum fluctuations reflecting greater resilience in cows. With automatic milking systems, multiple records can be obtained from many cows on a daily basis. Given that animals are continually exposed to a range
M. Agyiri +7 more
wiley +1 more source
The use of the Comet assay for understanding the biological activities of metal-based drugs
, 2009 PINELLI, Silvana +5 more
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