Results 271 to 280 of about 1,981,264 (328)
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Environmental Pollution
The paper provides the first assessment of the occurrence of hormetic dose responses using the Comet assay, a genotoxic assay. Using a priori evaluative criteria based on the Hormetic Database on peer-reviewed comet assay experimental findings, numerous examples of hormetic dose responses were obtained.
Edward J. Calabrese, Paul B. Selby
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The paper provides the first assessment of the occurrence of hormetic dose responses using the Comet assay, a genotoxic assay. Using a priori evaluative criteria based on the Hormetic Database on peer-reviewed comet assay experimental findings, numerous examples of hormetic dose responses were obtained.
Edward J. Calabrese, Paul B. Selby
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2009
Among the manifold advantages of the Comet assay is the ability to evaluate very limited amounts of test agents. In many cases compounds for a research study are not commercially available and the chemicals must be individually synthesised at great expense and with large amounts of time involved.
Elizabeth D. Wagner, Michael J. Plewa
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Among the manifold advantages of the Comet assay is the ability to evaluate very limited amounts of test agents. In many cases compounds for a research study are not commercially available and the chemicals must be individually synthesised at great expense and with large amounts of time involved.
Elizabeth D. Wagner, Michael J. Plewa
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Miniaturizing the comet assay with 3D vertical comets
Cytometry Part A, 2002AbstractBackgroundThe comet or single‐cell gel electrophoresis assay is a sensitive method for the detection of DNA damage. The main drawback of comet sampling is the low cell density necessary to prevent nucleus overlap after electrophoresis, which limits large‐scale high throughput screening. Another problem may be inconsistent comet focusing.
Philippe, Baert, Patrick, Van Oostveldt
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Comet assay and early apoptosis
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2001The comet assay is a single cell gel electrophoresis test currently used as a qualitative and quantitative genotoxicity test. However, some of the results from this comet assay and current knowledge on apoptosis lead us to suspect the presence of some false positive results.
P, Choucroun +4 more
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Comet assay in neonatal sepsis
The Indian Journal of Pediatrics, 2010To determine whether the DNA damage detected using the Comet assay helps in the diagnosis of neonatal sepsisSepsis was diagnosed, based on clinical findings, laboratory findings and positive culture results, in 24 of the 48 newborns who participated in the study.
Natália C, Carvalho +3 more
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Acellular comet assay: a tool for assessing variables influencing the alkaline comet assay
Radiation Protection Dosimetry, 2011In this study, an acellular modification to the alkaline comet assay to further evaluate key variables within the assay that may influence the outcome of genotoxicity studies is described. This acellular comet assay can detect differences of 0.2 Gy of (60)Co gamma-ray radiation between 0 and 1 Gy and differences of 1 Gy between 0 and 8 Gy; thus, this ...
Erin K, Kennedy +4 more
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Genotoxicity of Contaminants: Comet Assay
2013International ...
Devaux, Alain, Bony, Sylvie
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Comet assay to sense neutron ‘fingerprint’
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2000The suitability of comet assay to identify DNA damage induced by neutrons of varying energy was tested. For this purpose, monoenergetic neutrons from Hiroshima University Radiobiological Research Accelerator (HIRRAC) were used to induce DNA damage in irradiated human peripheral blood lymphocytes.
N, Gajendiran, K, Tanaka, N, Kamada
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Comet assay on tetraploid yeast cells
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2009Tetraploid yeast cells (Saccharomyces cerevisiae) were used in the comet assay with the intention of developing a new, fast and easy assay for detecting environmental genotoxic agents without using higher organisms. Two DNA-damaging chemicals, H(2)O(2) and acrylamide, together with wastewater from three municipal treatment plants were tested for their ...
Jette, Rank +2 more
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Environmental Monitoring & Assessment, 2020
Luís F. O. Knapik, W. Ramsdorf
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Luís F. O. Knapik, W. Ramsdorf
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