Results 41 to 50 of about 7,027 (228)

On the Early Thermal Processing of Planetesimals during and after the Giant Planet Instability

The Planetary Science Journal
Born as ice-rich planetesimals, cometary nuclei were gravitationally scattered onto their current orbits in the Kuiper Belt and the Oort Cloud during the giant planets’ dynamical instability in the early stages of our solar system’s history.
Anastasios Gkotsinas, David Nesvorný, Aurélie Guilbert-Lepoutre, Sean N. Raymond, Nathan Kaib   +4 more
doaj   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Jupiter Co-Orbital Comet P/2023 V6 (PANSTARRS): Orbital History and Modern Activity State

The Astrophysical Journal Letters
The discovery of the transient Jupiter co-orbital comet P/2019 LD2 (ATLAS) drew significant interest. Not only will LD2 transition between being a Centaur and a Jupiter-family comet (JFC) in 2063, the first time this process can be observed as it happens,
Theodore Kareta, John W. Noonan, Kathryn Volk, Ryder H. Strauss, David Trilling   +4 more
doaj   +1 more source

Alpha 7 nicotinic receptors attenuate neurite development through calcium activation of calpain at the growth cone.

PLoS ONE, 2018
The α7 nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that plays an important role in cellular calcium signaling contributing to synaptic development and plasticity, and is a key drug target for the treatment of neurodegenerative ...
Justin R King, Nadine Kabbani
doaj   +1 more source

Comparing the dynamics of Jupiter-family Comets and comet-like fireballs

Astronomy & Astrophysics
Context. Jupiter-family comets (JFCs), which originate from the Kuiper belt and scattered disk, exhibit low-inclination and chaotic trajectories due to close encounters with Jupiter. Despite their typically short incursions into the inner solar system, a notable number of them are on Earth-crossing orbits, with fireball networks detecting many objects ...
P. M. Shober, G. Tancredi, J. Vaubaillon, H. A. R. Devillepoix, S. Deam, S. Anghel, E. K. Sansom, F. Colas, S. Martino   +8 more
openaire   +6 more sources

Endogenous Amplification of Apoptosis via p53 Regulation using a Cascade Nanocatalytic Medicine

Advanced Science, EarlyView.
An engineered MOF nanomedicine (MAL) triggers cascade nanocatalysis in tumors, converting H2O2 and L‐Arg into cytotoxic peroxynitrite. This induces DNA damage, activates the p53 pathway, and amplifies mitochondrial apoptosis via the BAX/Bcl‐2/Caspase‐3 axis, effectively inhibiting colorectal cancer growth with high biocompatibility.
Tan Wu, Xiaoyue Xu, Dan Xu, Hui Zhang, Nan Wang, Yang Yang, Qian Chen, Shunjie Chen, Cheng Li   +8 more
wiley   +1 more source

Gauss-Radau Small-body Simulator (GRSS): An Open-source Library for Planetary Defense

The Planetary Science Journal
We present GRSS , a small-body propagation and orbit determination library specifically designed for planetary defense applications. GRSS is an end-to-end, open-source software tool that begins with optical observations obtained from the Minor Planet ...
Rahil Makadia, Davide Farnocchia, Steven R. Chesley, Siegfried Eggl   +3 more
doaj   +1 more source

Plasma Dynamics in Comets I. Plasma Instability.

The Astrophysical Journal, 1962
Biermann suggested that ionized gas clouds in comet tails are accelerated by collision with a stream of solar particles. The field-free case is discussed to establish conditions for which cometary plasma acceleration may be enhanced by plasma instability.
Fred Hoyle, Martin Harwit
openaire   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source