Doxorubicin (DOX)‐induced cardiotoxicity is a major limitation to its broader clinical application, while cardioprotective interventions often risk reducing the anticancer efficacy of DOX. To address these challenges, this work constructs an EDTA‐functionalized metal–organic framework that enhances tumor therapy and provides efficient cardioprotection ...
Daojing Yuan +8 more
wiley +1 more source
MTB-3, a microtubule plus-end tracking protein (+TIP) of Neurospora crassa. [PDF]
The microtubule (MT) "plus end" constitutes the platform for the accumulation of a structurally and functionally diverse group of proteins, collectively called "MT plus-end tracking proteins" (+TIPs). +TIPs control MT dynamics and link MTs to diverse sub-
Rosa R Mouriño-Pérez +6 more
doaj +1 more source
Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng +11 more
wiley +1 more source
Carbon Speciation and Solubility in Silicate Melts
This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Natalia Solomatova +2 more
wiley +2 more sources
A Dormant Captured Oort Cloud Comet Awakens: (18916) 2000 OG44
We report the discovery of activity emanating from (18916) 2000 OG _44 (alternately designated 1977 SD), a minor planet previously reported to be both an extinct comet and an asteroid on a cometary orbit. We observed 2000 OG _44 with a thin tail oriented
Colin Orion Chandler +4 more
doaj +1 more source
Dynamical Population of Comet Reservoirs
The Oort cloud and the scattered disk are the two primary reservoirs for long-period and short-period comets, respectively. In this review, we assess the known observational constraints on these reservoirs' properties and their formation. In addition, we discuss how the early orbital evolution of the giant planets generated the modern scattered disk ...
Kaib, Nathan A., Volk, Kathryn
openaire +2 more sources
Alternative Policy Designs to Help Farmers Select Profitable Conservation Practices
ABSTRACT Voluntary private carbon initiatives (VPCIs) promote the implementation of agricultural conservation practices that mitigate emissions of greenhouse gases (GHGs) via financial incentives to participating farmers. Simultaneously, an array of public policies supports the adoption of conservation practices through technical and financial ...
Oranuch Wongpiyabovorn +1 more
wiley +1 more source
Crater Observing Bioinspired Rolling Articulator (COBRA)
Crater Observing Bio‐inspired Rolling Articulator (COBRA) is a modular, snake‐inspired robot that addresses the mobility challenges of extraterrestrial exploration sites such as Shackleton Crater. Incorporating snake‐like gaits and tumbling locomotion, COBRA navigates both uneven surfaces and steep crater walls.
Adarsh Salagame +4 more
wiley +1 more source
This article reveals how calcium content, mineral nanostructure, and lacuno‐canalicular network (LCN) organization interact to shape bone heterogeneity in mouse tibiae. Advanced multimodal imaging uncovers that mechanical loading promotes mature mineral structures even in low‐calcium regions, highlighting LCN‐driven mineralization and offering new ...
Victoria Schemenz +10 more
wiley +1 more source
The Effect of Solar-Wind Turbulence on Magnetospheric Activity
The solar wind is a highly turbulent medium exhibiting scalings of the fluctuations ranging over several decades of scales from the correlation length down to proton and electron gyroradii, thus suggesting a self-similar nature for these fluctuations ...
R. D’Amicis, D. Telloni, R. Bruno
doaj +1 more source

