Results 101 to 110 of about 8,432 (197)

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, Volume 13, Issue 41, 22 July 2026.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, Volume 13, Issue 39, 13 July 2026.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Evaluation of genotoxic activity of maleic hydrazide, ethyl methane sulfonate, and N-nitroso diethylamine in Tradescantia Evaluación de la genotoxicidad de hidrazida málica, N-nitroso dietilamina, y etil metano sulfonato, en núcleos de Tradescantia, por medio de la prueba del cometa

Salud Pública de México, 2001
Objective. To assess the genotoxic activity of N-nitroso diethylamine (NDEA), maleic hydrazide (MH), and ethyl methane sulfonate (EMS) using two systems: the comet assay on nuclei from Tradescantia, and the pink mutation test on Tradescantia staminal ...
Carlos Alvarez-Moya, Anne Santerre-Lucas, Guillermo Zúñiga-González, Olivia Torres-Bugarín, Eduardo Padilla-Camberos, Alfredo Feria-Velasco   +5 more
doaj  

Investigation of Split Comet 240P/NEAT

The Astronomical Journal
We present time-series observations of the split comet 240P/NEAT near perihelion, obtained using the Nordic Optical Telescope. The brighter component, 240P-A, has an estimated radius in the range 400–600 m, and loses dust at the peak rate 130 kg s ^−1 ...
David Jewitt, Jane Luu, Yoonyoung Kim
doaj   +1 more source

Chemical Characterization and In Vivo Safety Assessment of Aqueous Extract From Anacardium occidentale L. (Anacardiaceae) Leaves

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
Anacardium occidentale leaf aqueous extract showed rich polyphenolic composition, including flavonoids, tannins, and phenolic acids. Acute toxicity in mice revealed no mortality or adverse effects, with LD50 >2000 mg/kg and GHS Class 5. Genotoxicity assays were negative, supporting safety and potential phytopharmaceutical development, pending chronic ...
Elinado Francisco de Lima Bento, Caio Everton Nunes da Silva, Talita Giselly dos Santos Souza, Camylla Janiele Lucas Tenório, Natanael Teles Ramos de Lima, Cristiano Aparecido Chagas, José Maria Barbosa Filho, Magda Rhayanny Assunção Ferreira, Luiz Alberto Lira Soares, Samuel Paulo Cibulski, Alisson Macário de Oliveira, Thiago Henrique Napoleão   +11 more
wiley   +1 more source

In Vitro Antineoplastic Effects of Zataria multiflora: A Systematic Review of Mechanisms, Selectivity, and Synergy

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Zataria multiflora (ZM) is an aromatic plant containing various bioactive components, including phenolic compounds, flavonoids, and terpenoids. Here, we systematically review 27 articles to explore the effect of ZM on different cancer/normal cell lines.
Alireza Khanahmad, Fatemeh Peymaninezhad, Fariba Sharififar, Ali Sadatmoosavi, Ali Bazi, Roohollah Mirzaee Khalilabadi, Hajar Mardani Valandani   +6 more
wiley   +1 more source

Mammalian Osteoderm Ultrastructure in the Armored Acomys Spiny Mouse Tail

Small, Volume 22, Issue 40, 17 July 2026.
The ultrastructure of armored platelets – termed osteoderms – in the tail skin of Acomys cahirinus spiny mice is characterized using 2D and 3D microscopy methods. The imbricated structure is composed of calcium phosphate biomineral and has select structural elements that are bone‐like and tooth‐like in nature.
Joseph Deering, Malcolm Maden, Marc D. McKee   +2 more
wiley   +1 more source

The Magnetic Mineralogy of Carbonaceous Chondrites: A Microscopy and Machine Learning Study of Meteorite WIS 91600

Geochemistry, Geophysics, Geosystems, Volume 27, Issue 7, July 2026.
Abstract A central challenge in the paleomagnetic study of meteorites is to characterize their diverse remanence carriers. Here, we develop a machine‐learning assisted workflow that combines multi‐scale (mm to nm) and multi‐dimensional (2D‐3D) microscopy to build a comprehensive picture of ferromagnetic mineralogy in the C2 ungrouped carbonaceous ...
Richard J. Harrison, Po‐Yen Tung, Thomas Ginnis, Farhang Nabiei, Ursula Shaw, Elias N. Mansbach, James Bryson   +6 more
wiley   +1 more source

Geodetic Constraints on Fault Kinematics and Dynamics of 2021 Maduo Earthquake: Implications for Fault Friction

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 7, July 2026.
Abstract Postseismic afterslip has been inferred to occur on fault barriers surrounding coseismic asperities, which can be explained by velocity‐strengthening friction in barriers and velocity‐weakening friction in asperities. However, afterslip also exhibits spatial overlap with coseismic slip for some events.
Yuan Gao, Qi Ou, Jin Fang, Manon Carpenter, Tim J. Wright, Kali Allison, Wei Qu, Qin Zhang, Milan Lazecký, Yasser Maghsoudi, Zhong Lu   +10 more
wiley   +1 more source

Cosmic Dust Flux During the Quaternary: The Record of Large Scoriaceous and Unmelted Micrometeorites From the Transantarctic Mountains Collection

Journal of Geophysical Research: Planets, Volume 131, Issue 7, July 2026.
Abstract We estimate the cosmic dust flux to Earth through the study of rare micrometeorites that preserve part of their precursor features during atmospheric entry heating, namely unmelted and scoriaceous subtypes. Combining high‐precision mass balance measurements, X‐ray computed microtomography and scanning electron microscopy, we studied mass, size
S. Ottaviani, L. Folco, M. D. Suttle, R. Repič, L. Mancini, T. Battiston, S. Iannini Lelarge, M. Masotta   +7 more
wiley   +1 more source