Results 31 to 40 of about 9,305 (228)

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

ON COLLISION OF SECONDARY NUCLEI OF COMET P/SHOEMAKER-LEVI 9 (1993E) WITH JUPITER

Odessa Astronomical Publications, 2017
In July 1994 the comet P/Shoemaker-Levi which in July 1992 split in the Roche lobe of Jupiter onto 21 fragments, then collided with Jupiter at the altitude near – 45°.
K. I. Churyumov, V. G. Kruchinenko
doaj   +1 more source

Splitting of Long-period Comet C/2018 F4 (PANSTARRS)

The Astronomical Journal, 2023
Long-period comet C/2018 F4 (PANSTARRS) was observed to show duplicity of its inner region in 2020 September, suggestive of a splitting event. We here present analyses of our observations of the comet taken from the LCO Outbursting Objects Key project ...
Man-To Hui, Michael S. P. Kelley, Denise Hung, Tim Lister, Joseph Chatelain, Edward Gomez, Sarah Greenstreet   +6 more
doaj   +1 more source

The loss and depth of CO2 ice in comet nuclei [PDF]

Icarus, 1987
The chemical differentiation of a homogeneous, initially unmantled cometary nucleus whose composition encompasses water ice, unclathrated CO2 ice, and silicate dust, is presently simulated by an analytical model to test whether the selective sublimation of any free CO2 ice in the new comet will produce a surface layer of water ice and dust covering the
Fraser P. Fanale, James R. Salvail
openaire   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Parent Volatile Outgassing Associations in Cometary Nuclei: Synthesizing Rosetta Measurements and Ground-based Observations

The Planetary Science Journal
Comets, as remnants of the solar system’s formation, vary in volatile-refractory content. In situ comet studies, such as the Rosetta mission to 67P/Churyumov–Gerasimenko, provide detailed volatile composition insights, while ground-based studies offer ...
Mohammad Saki, Dennis Bodewits, Boncho P. Bonev, Neil Dello Russo, Adrienn Luspay-Kuti, John W. Noonan, Michael. R. Combi, Yinsi Shou   +7 more
doaj   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Conditions for the formation of anomalous tail of comet

Open Astronomy, 2019
The time and velocity of ejection of dust particles of anomalous tails from cometary nuclei are determined. It is revealed that some comets cause the formation of an anomalous tail is the collision of their comet nucleus with other bodies of the Solar ...
Safarov Abduljalol G., Ibadinov Khursand I.   +1 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source