Results 31 to 40 of about 312,980 (227)

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

The loss and depth of CO2 ice in comet nuclei [PDF]

Icarus, 1987
The chemical differentiation of a homogeneous, initially unmantled cometary nucleus whose composition encompasses water ice, unclathrated CO2 ice, and silicate dust, is presently simulated by an analytical model to test whether the selective sublimation of any free CO2 ice in the new comet will produce a surface layer of water ice and dust covering the
Fraser P. Fanale, James R. Salvail
openaire   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Parent Volatile Outgassing Associations in Cometary Nuclei: Synthesizing Rosetta Measurements and Ground-based Observations

The Planetary Science Journal
Comets, as remnants of the solar system’s formation, vary in volatile-refractory content. In situ comet studies, such as the Rosetta mission to 67P/Churyumov–Gerasimenko, provide detailed volatile composition insights, while ground-based studies offer ...
Mohammad Saki, Dennis Bodewits, Boncho P. Bonev, Neil Dello Russo, Adrienn Luspay-Kuti, John W. Noonan, Michael. R. Combi, Yinsi Shou   +7 more
doaj   +1 more source

ON COLLISION OF SECONDARY NUCLEI OF COMET P/SHOEMAKER-LEVI 9 (1993E) WITH JUPITER

Odessa Astronomical Publications, 2017
In July 1994 the comet P/Shoemaker-Levi which in July 1992 split in the Roche lobe of Jupiter onto 21 fragments, then collided with Jupiter at the altitude near – 45°.
K. I. Churyumov, V. G. Kruchinenko
doaj   +1 more source

Ameliorative potential of β-1,3-D-Glucan on acrylamide-induced cytogenetic alterations in mice. [PDF]

Journal of Bioscience and Applied Research, 2016
Acrylamide (AA) is formed in food during heat preparation (frying and baking), causing DNA toxicity. So, the aim of this study is applied β-1,3-D-Glucan (BDG) as a natural polysaccharide ameliorative to reduce the DNA hepatotoxicity and genotoxicity of ...
Mohamed A. Ismail
doaj   +1 more source

Predictions of the solar wind interaction with Comet Grigg-Skjellerup [PDF]

, 1992
The planned encounter of the Giotto spacecraft with comet Grigg-Skjellerup on 10th July 1992 promises to extend our knowledge of the solar wind interaction with comets substantially.
Johnstone, AD, Huddleston, DE, Coates, AJ   +2 more
core  

Saharan dust and ice nuclei over Central Europe [PDF]

, 2010
Surface measurements of aerosol and ice nuclei (IN) at a Central European mountain site during an episode of dust transport from the Sahara are presented.
B. Nillius, Levin, Zev, Barrie, Leonard A., Nillius, Björn, M. Ebert, Bingemer, Heinz, S. Weinbruch, Ebert, Martin, Nickovic, Slobodan, Haunold, Werner, H. Klein, U. Bundke, Klein, Holger, Bundke, Ulrich, Weinbruch, Stephan, H. Bingemer, L. Schuetz, Z. Levin, Schuetz, Lothar, L. A. Barrie, S. Nickovic, W. Haunold   +21 more
core   +2 more sources

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Conditions for the formation of anomalous tail of comet

Open Astronomy, 2019
The time and velocity of ejection of dust particles of anomalous tails from cometary nuclei are determined. It is revealed that some comets cause the formation of an anomalous tail is the collision of their comet nucleus with other bodies of the Solar ...
Safarov Abduljalol G., Ibadinov Khursand I.   +1 more
doaj   +1 more source