Results 51 to 60 of about 9,305 (228)

Silencing SGO2 by Oxamic Acid Dissociates Glycolysis and BRCA1‐Mediated DNA Repair to Improve the Chemosensitivity of Lung Adenocarcinoma

Exploration, EarlyView.
SGO2 interacts with BRCA1 to inhibit BRCA1 ubiquitination and degradation, thereby promoting BRCA1‐induced DNA damage repair signaling and reducing the chemo sensitivity of LUADa. OA targets glycolysis to disrupt H3K18la‐ and H3K27ac‐mediated chromatin accessibility, repressing SGO2 transcription and subsequently alleviating SGO2‐mediated cancer ...
Xian Lin, Zhidan Hua, Chen Liu, Minxia Yang, Beilei Zhang, Xiaofeng Zhu, Xiao Chen   +6 more
wiley   +1 more source

Evaluation of genetic damage induced by glyphosate isopropylamine salt using Tradescantia bioassays

Genetics and Molecular Biology, 2011
Glyphosate is noted for being non-toxic in fishes, birds and mammals (including humans). Nevertheless, the degree of genotoxicity is seriously controversial.
Carlos Alvarez-Moya, Mónica Reynoso Silva, Alma Rosa Villalobos Arámbula, Alfonso Islas Sandoval, Hugo Castañeda Vasquez, Rosa María González Montes   +5 more
doaj  

The Large Smooth Patch on Comet 9P/Tempel 1: Remnant of a Recent Past Event

The Planetary Science Journal
We present a comprehensive reassessment of the region containing the large smooth patch on comet 9P/Tempel 1, leveraging data from the Deep Impact and Stardust-NExT missions, an updated stereophotoclinometry-based shape model, and numerical simulations ...
J. L. Rizos, T. L. Farnham, J. M. Sunshine, J. L. Kloos, J. L. Ortiz   +4 more
doaj   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

The nature of comet-asteroid transition object (3200) Phaethon

, 2007
Context. The study of asteroids that present sporadic cometary activity is of fundamental importance to address several astronomical problems including the end states of comet nuclei, the abundance of water in main belt asteroids, and its role as a ...
Pinilla-Alonso, N., T. Mothé-Diniz, H. Campins, Campins, H., J. Licandro, De León, J., J. de León, Licandro, J., N. Pinilla-Alonso, Mothé-Diniz, T.   +9 more
core   +2 more sources

Postperihelion Coma Composition of the Interstellar Comet 3I/ATLAS from Optical Spectroscopy

The Astrophysical Journal Letters
We present multiepoch optical spectroscopy of the interstellar comet 3I/ATLAS obtained between 2025 December and 2026 January (heliocentric distances of 1.8–3.3 au), yielding postperihelion production rates and mixing ratios for CN, C _3 , C _2 , CH, and
Ruining Zhao, Xiliang Zhang, Bin Yang, Xiangyu Fan, Shu Wang, Yang Huang, Jifeng Liu   +6 more
doaj   +1 more source

Anti‐inflammatory and cytotoxic properties of kānuka (Kunzea ericoides) subcritical water extract

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Kānuka (Kunzea ericoides) is a medicinal plant native to New Zealand with numerous therapeutic benefits due to its rich bioactive profile. Although several in vitro studies have shown promising anti‐inflammatory activity, substantial evidence elucidating its underlying inflammatory regulatory mechanism and evaluating its cytotoxic ...
Indhuja Devadass, Simon Swift, Saeid Baroutian   +2 more
wiley   +1 more source

Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Yuan Ma, Ying Li, Kai‐Li Li
wiley   +1 more source

Nuclear spectra of comet 28P Neujmin

, 2007
We present visible and near-infrared spectra of the nucleus of comet 28P/Neujmin 1, obtained in 2001, 2002, and 2003, while it had no detectable coma.
Mothé-Diniz, Thais, Hergenrother, Carl, Guerra, Juan C., Ziffer, Kulie, Campins, Humberto, Licandro, Javier, León, Julia De, Pinilla-Alonso, Noemí   +7 more
core   +1 more source

Comparative study of water ice exposures on cometary nuclei using multispectral imaging data [PDF]

, 2016
The ESLAB 50 Symposium - spacecraft at comets from 1P/Halley to 67P/Churyumov-GerasimenkoInternational audienceDeep Impact, EPOXI and Rosetta missions visited comets 9P/Tempel 1, 103P/Hartley 2 and 67P/Churyumov-Gerasimenko respectively.
Lamy, P., Lin, Z. -Y, Guettler, C., Kuehrt, E., Oklay, N.,, Bertaux, J. -L., Hofmann, M., Kovacs, G., Thomas, Nicolas, Debei, S.,, Lopez Moreno, J. J.,, Debei, Stefano, Preusker, F.,, Keller, H. U., Sierks, H., A'Hearn, M. F.,, Scholten, F., Lin, Z.-Y., Ip, W., Bertini, Ivano, Shi, X., Pajola, M., Debei, S., Pommerol, A., Gicquel, Adeline, Bertaux, J. -L, Davidsson, B., Bertaux, J. -.L., Hofmann, M.,, Naletto, G., Vincent, J. -.B., Vincent, J.-B., Lamy, P. L., Fulle, M., Kramm, J. -R, De Cecco, M.,, Shi, X.,, Bodewits, Dennis, Hviid, S., Knollenberg, J., Preusker, F., Lamy, Philippe L., Thomas, N., Guettler, C.,, Kührt, E., Vincent, J., Naletto, G.,, Fulle, M.,, Lara, L., Groussin, O.,, Kramm, J.-R., Gutiérrez, Pedro J., Sunshine, J. M., Barucci, M., Ip, W. -.H., Hall, I.,, Sierks, Holger, Da Deppo, V., Sunshine, Jessica M., Vincent, J. -B., Lopez Moreno, J. J., da Deppo, Vania, Rodrigo, R., Gicquel, A., Gicquel, A.,, Tubiana, C., Preusker, Frank, Davidsson, B. J. R., Pommerol, Antoine, Rickman, H., Jorda, L.,, Hviid, Stubbe F., Deller, J.,, Vincent, Jean-Baptiste, Groussin, O., Oklay, Nilda, Güttler, C., Sunshine, J., Barucci, M. A., Vincent, J. -B, Barucci, M. A.,, Kramm, J. -.R., Kuehrt, E.,, Bertaux, J.-L., A'Hearn, Michael F., Fulle, Marco, De Cecco, M., Fornasier, S.,, Kuppers, M.,, Lara, Luisa M., Barbieri, Cesare, Koschny, D.,, Lazzarin, M., Lazzarin, M.,, Gutierrez, P. J.,, Bertaux, Jean-Loup, Gutierrez, P. J., Barbieri, C., Davidsson, Björn J. R., Koschny, Detlef, Thomas, N.,, Groussin, Olivier, Rickman, Hans, Koschny, D., Sunshine, J. M.,, Mottola, Stefano, Oklay, N., A'Hearn, M. F., Pajola, Maurizio, Tubiana, C.,, Lamy, P. L.,, Davidsson, B. J. R.,, Kovacs, G.,, Rickman, Hans,, Bertini, I., Lin, Z. -Y., Hall, I., Deller, J., Gutierrez, P., de Cecco, Mariolino, Scholten, F.,, Ip, W.-H., Fornasier, S., Kührt, Ekkehard, Güttler, Carsten, Ip, W. -H, Bodewits, D.,, Scholten, Frank, Kramm, J. -R., Jorda, L., Bodewits, D., Barbieri, C.,, Pajola, M.,, Barucci, M. Antonella, Deller, Jakob, Rodrigo, R.,, Da Deppo, V.,, Ip, W. -H., Lara, L. M.,, Keller, H. U.,, Lin, Z., Kramm, J., Cremonese, Gabriele, Bertaux, J., Lin, Z. -.Y., Cremonese, G., Keller, H., Sierks, H.,, Rodrigo, Rafael, Pommerol, A.,, Mottola, S.,, Marzari, F.,, Lopez Moreno, J., Cremonese, G.,, Mottola, S., Küppers, M., Fornasier, Sonia, A'Hearn, M., Hviid, S. F.,, Lara, L. M., Thomas, Nicholas, Hviid, S. F., Knollenberg, J.,, Bertini, I.,, Marzari, F.   +164 more
core   +1 more source