Results 61 to 70 of about 312,980 (227)

Redistribution of DNA loop domains in human lymphocytes under blast transformation with interleukin 2 [PDF]

The Ukrainian Biochemical Journal, 2016
At higher order levels chromatin fibers in interphase nuclei are organized into loop domains. Gene regulatory elements (promoters and enhancers) are often located near the sites of loop attachments.
K. S. Afanasieva, M. I. Chopei, A. V. Lozovik, S. R. Rushkovsky, A. V. Sivolob   +4 more
doaj   +1 more source

The Comet Interceptor mission to a dynamically new comet

, 2023
openL'elaborato mira ad affrontare il problema del tipo di manovre orbitali richieste per lo scopo della missione Comet Interceptor, ovvero il raggiungimento di un fly-by attorno a una cometa dinamicamente nuova proveniente dalla regione esterna al ...
SIMULA, SUSANNA
core  

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

NSF-DOE Vera C. Rubin Observatory Observations of Interstellar Comet 3I/ATLAS (C/2025 N1)

The Astrophysical Journal Letters
We report on the observation and measurement of astrometry, photometry, morphology, and activity of the interstellar object 3I/ATLAS, also designated C/2025 N1 (ATLAS) with the NSF-DOE Vera C. Rubin Observatory.
Colin Orion Chandler, Pedro H. Bernardinelli, Mario Jurić, Devanshi Singh, Henry H. Hsieh, Ian Sullivan, R. Lynne Jones, Jacob A. Kurlander, Dmitrii Vavilov, Siegfried Eggl, Matthew Holman, Federica Spoto, Megan E. Schwamb, Lauren A. MacArthur, Rahil Makadia, Marco Micheli, Aren Heinze, Eric J. Christensen, Wilson Beebe, Aaron Roodman, Kian-Tat Lim, Tim Jenness, James Bosch, Brianna M. Smart, Eric Bellm, Sean MacBride, Meredith L. Rawls, Sarah Greenstreet, Colin Slater, Željko Ivezić, Robert D. Blum, Andrew Connolly, Gregory Daues, Michelle Gower, J. Bryce Kalmbach, Michele T. Bannister, Luke Dones, Rosemary C. Dorsey, Davide Farnocchia, Wesley C. Fraser, John C. Forbes, Cesar Fuentes, Carrie E. Holt, Laura Inno, Geraint H. Jones, Matthew M. Knight, Chris J. Lintott, Tim Lister, Robert Lupton, Mark Jesus M. Magbanua, Renu Malhotra, Beatrice E. A. Mueller, Joseph Murtagh, Nitya Pandey, William T. Reach, Nalin H. Samarasinha, Darryl Z. Seligman, Colin Snodgrass, Michael Solontoi, Gyula M. Szabó, Peter Vereš, Ellie White, Maria Womack, Leslie A. Young, Russ Allbery, Shreya Anand, Roberto Armellin, Éric Aubourg, Chrysa Avdellidou, Farrukh Azfar, James Bauer, Keith Bechtol, Valerie Becker, Matthew Belyakov, Susan D. Benecchi, Ivano Bertini, Dennis Bodewits, Patricia Boeshaar, Bryce T. Bolin, Maitrayee Bose, Alexandre Boucaud, Rodrigo C. Boufleur, Dominique Boutigny, Andrew Bradshaw, Felipe Braga-Ribas, Johan Bregeon, Laura E. Buchanan, Daniel Calabrese, J. I. B. Camargo, Neven Caplar, Jeffrey L. Carlin, Benoit Carry, Juan Pablo Carvajal, Ross Ceballo, Hsin-Fang Chiang, Yumi Choi, Céline Combet, Luiz da Costa, Preeti Cowan, John Franklin Crenshaw, Steve Croft, Matija Ćuk, Philip N. Daly, Filippo D’Ammando, Felipe Daruich, Guillaume Daubard, James R. A. Davenport, Tansu Daylan, Jennifer Delgado, Hadrien A. R. Devillepoix, Peter E. Doherty, Abbie Donaldson, Holger Drass, Stephanie J. H. Deppe, Gregory P. Dubois-Felsmann, Peter S. Ferguson, Frossie Economou, Marielle R. Eduardo, Ioana Sotuela Elorriaga, Anthony Englert, Edward Karavakis, Kevin Fanning, Maxwell K. Frissell, Grigori Fedorets, Maryann Benny Fernandes, Agnès Ferté, Merlin Fisher-Levine, Mark L Freytag, Marco Fulle, Poshak Gandhi, John Gates, David W. Gerdes, Alex R. Gibbs, A. Fraser Gillan, Massimiliano Giordano Orsini, T. Glanzman, Iain Goodenow, Altair Ramos Gomes-Júnior, Miranda R. Gorsuch, Mikael Granvik, Wen Guan, Leanne P. Guy, Mark Hammergren, Andrew Hanushevsky, Fabio Hernandez, Ǎdis Herrold, Daniel Hestroffer, Joshua Hoblitt, Guillem Megias Homar, Matthew J. Hopkins, Simone Ieva, Patrick Ingraham, David H. Irving, Buell T. Jannuzi, M. James Jee, David Jimenez, Claire Juramy, Steven M. Kahn, Yijung Kang, Arun Kannawadi, JJ Kavelaars, Michael S. P. Kelley, Kshitija Kelkar, Lee S. Kelvin, Ivan Kotov, Alec Koumjian, Gábor Kovács, K. Simon Krughoff, Agnieszka Kryszczyńska, Petr Kubánek, Craig Lage, Travis J. Lange, Pierre-François Léget, Laurent Le Guillou, Benjamin Levine, W. Garrett Levine, Zhuofu (Chester) Li, Shuang Liang, Javier Licandro, Hsing Wen Lin, Carey Lisse, Nate B. Lust, Ryan R. Lyttle, Ashish A. Mahabal, Max Mahlke, Gabriele Mainetti, Rachel Mandelbaum, Steven J. Margheim, Giuliano Margoti, Phil Marshall, Andrés A. Plazas Malagón, Dušan Marčeta, Mario D. Melita, Felipe Menanteau, Joshua Meyers, Dave Mills, Marc Moniez, C.A.L. Morales Marín, Naomi Morato, Surhud More, Christopher B. Morrison, Kris Mortensen, Youssef Moulane, Karlo Mrakovčić, Fritz Mueller, Marco A. Muñoz-Gutiérrez, Homer Neal, F. M. Newcomer, Erfan Nourbakhsh, Paul O’Connor, Drew Oldag, William J. Oldroyd, William O’Mullane, Cyrielle Opitom, Dagmara Oszkiewicz, Gary L. Page, Jack Patterson, Maria T Patterson, Matthew J. Payne, Eske M. Pedersen, Julien Peloton, Chrystian Luciano Pereira, John R. Peterson, Stephen R. Pietrowicz, Edyta Podlewska-Gaca, Rebekah Polen, Daniel Polin, Hannah Mary Margaret Pollek, Yongqiang Qiu, Bruno Quint, Markus Rabus, Darin Ragozzine, Jayadev Rajagopal, Arianna Ranabhat, Kevin Reil, Tiago Ribeiro, Malena Rice, Stephen T. Ridgway, Steven M. Ritz, Andrew S. Rivkin, James E. Robinson, Agata Rożek, Eli Rykoff, Luis E. Salazar Manzano, Andrei Salnikov, Bruno O. Sánchez, David Sanmartim, Gal Sarid, Charles A. Schambeau, Rafe H. Schindler, Samuel J. Schmidt, German Schumacher, Theo Schutt, Daniel Scolnic, Robert Seaman, Jacques Sebag, Nima Sedaghat, Jacqueline Seron, Richard A. Shaw, Alysha Shugart, Jonathan Sick, Jaladh Singhal, Amir Siraj, Michael C. Sitarz, Adam Snyder, Shahram Sobhani, Christine Soldahl, Dallin Spencer, Brian Stalder, Steven Stetzler, Alan Strauss, Christopher W. Stubbs, Krzysztof L. Suberlak, John D. Swinbank, László Szigeti, Dan S. Taranu, Michael Tauraso, John Gregg Thayer, Sandrine Thomas, Adam Thornton, Luca Tonietti, Laura Toribio San Cipriano, David E. Trilling, Chadwick A. Trujillo, Te-Wei Tsai, Douglas L. Tucker, Max Turri, Tony Tyson, Elana K. Urbach, Wouter van Reeven, Antonia Sierra Villarreal, Stelios Voutsinas, Christopher W. Walter, Yuankun (David) Wang, Charlotte Ward, Michael Warner, Maxine West, Emerson Whittaker, Ian Wong, W. M. Wood-Vasey, Bin Yang, Quanzhi Ye, Peter Yoachim, R. Zanmar Sanchez, Jinshuo Zhang, Conghao Zhou   +305 more
doaj   +1 more source

Six Outbursts of Comet 46P/Wirtanen

The Planetary Science Journal, 2021
Cometary activity is a manifestation of sublimation-driven processes at the surface of nuclei. However, cometary outbursts may arise from other processes that are not necessarily driven by volatiles.
Michael S. P. Kelley, Tony L. Farnham, Jian-Yang Li, Dennis Bodewits, Colin Snodgrass, Johannes Allen, —, Eric C. Bellm, Michael W. Coughlin, Andrew J. Drake, Dmitry A. Duev, Matthew J. Graham, Thomas Kupfer, Frank J. Masci, Dan Reiley, Richard Walters, Zwicky Transient Facility Collaboration, M. Dominik, U. G. Jørgensen, A. E. Andrews, N. Bach-Møller, V. Bozza, M. J. Burgdorf, J. Campbell-White, S. Dib, Y. I. Fujii, T. C. Hinse, M. Hundertmark, E. Khalouei, P. Longa-Peña, M. Rabus, S. Rahvar, S. Sajadian, J. Skottfelt, J. Southworth, J. Tregloan-Reed, E. Unda-Sanzana, MiNDSTEp Collaboration   +37 more
doaj   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Yuan Ma, Ying Li, Kai‐Li Li
wiley   +1 more source

Finite difference time domain simulation of radar wave propagation through comet nuclei dielectric models

, 2008
The 90 MHz radar-wave experiment, Comet Nucleus Sounding Experiment by Radiowave Transmission (CONSERT), on board the Rosetta mission (ESA, 2004) is expected to probe the nucleus of the comet 67P/Churyumov-Gerasimenko (67P/C-G) to reveal information on ...
Carley, Ruth A., Heggy, Essam
core   +2 more sources

Modified comet assays for the detection of cyclobutane pyrimidine dimers and oxidative base damages

Journal of Radiation and Cancer Research, 2017
The comet assay (also known as single-cell gel electrophoresis) is a technique for the detection of DNA damage at the level of the individual cell. It is a versatile, relatively simple to perform and sensitive method.
Ganesan Muthusamy, Agilan Balupillai, Kanimozhi Govindasamy, Karthikeyan Ramasamy, Veeramani Kandan Ponniresan, Illiyas Magbool Malla, Rajendra Prasad Nagarajan   +6 more
doaj   +1 more source

Single Versus Double Screw Extrusion: Impact on Mechanical Performance and Crack Resistance for a Virgin, Recycled, and Blended Polypropylene

Polymer Engineering &Science, EarlyView.
Schematic overview of the study approach and key findings. ABSTRACT To evaluate the influence of extrusion on material performance, three processing methods, single extrusion (1x Ex), double extrusion (2x Ex), and double screw compounding (C), were investigated for virgin polypropylene (vPP), recycled PP (rPP), and a blend containing 10% rPP (rPP10 ...
J. Pötzlbauer, J. Geier, B. Haar, S. Schuschnigg, M. Messiha, T. Koch, C. Maurer, G. Pinter, F. Arbeiter   +8 more
wiley   +1 more source