Results 41 to 50 of about 329,629 (202)

MPP8 Facilitates DNA DSB Repair via NHEJ to Promote Chemoresistance of TNBC Independent of Methyl‐H3K9 Binding

Advanced Science, EarlyView.
Chemoresistance is often linked to elevated DNA repair. MPP8 is found to promote breast cancer chemoresistance as a novel NHEJ accessory factor independent of its epigenetic functions. Through multiple protein interactions, MPP8 facilitates association of DNAPK and ligase complexes to promote DNA repair progression.
Rupa Kumari, Jia Fang
wiley   +1 more source

ZNF865 (BLST) a Novel Regulator of DNA Damage and Cell Senescence in Back Pain [PDF]

Aging Cell
ZNF865 (BLST) has previously been classified as part of the “unknome”, but here in the context of back pain, we demonstrate the first functional characterization of ZNF865. We demonstrate that it regulates genomic stability and subsequent senescence, and that downregulation in the intervertebral disc leads to pain behavior in rodent models.
Lewis C, Levis H, Holbrook J, Polaski J, Jacobsen T, Mizels J, Czachor M, Gullbrand S, Diekman B, Iatridis J, Gertz J, Lawrence B, Bowles R.   +12 more
europepmc   +2 more sources

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Evaluation of genotoxic activity of maleic hydrazide, ethyl methane sulfonate, and N-nitroso diethylamine in Tradescantia

Salud Pública de México, 2001
Objective. To assess the genotoxic activity of N-nitroso diethylamine (NDEA), maleic hydrazide (MH), and ethyl methane sulfonate (EMS) using two systems: the comet assay on nuclei from Tradescantia, and the pink mutation test on Tradescantia staminal ...
Alvarez-Moya Carlos, Santerre-Lucas Anne, Zúñiga-González Guillermo, Torres-Bugarín Olivia, Padilla-Camberos Eduardo, Feria-Velasco Alfredo   +5 more
doaj  

On the role of collisions with meteoroids in splitting and acceleration of heliocentric velocity of comets

Open Astronomy, 2020
The hypothesis on the role of the meteoroid impacts in the comet nuclei splitting as well as acceleration of their heliocentric velocity are considered.
Guliyev Ayyub, Guliyev Rustam
doaj   +1 more source

Reactive torque influence onto rotation of comet nuclei. [PDF]

, 2002
: Reactive torques, due to anisotropic sublimation on a comet nucleus surface, produce slow variations of its rotation. In this paper the secular effects of this sublimation are studied.
Sidorenko V. V. http://library.keldysh.ru/author_page.asp?aid=1107, Neishtadt A.I., Vasiliev A.A., Ф.Стук, Scheeres D.J.   +4 more
core  

Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays

Cytoskeleton, EarlyView.
ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz, Benjamin Powers, Jayne Aiken   +2 more
wiley   +1 more source

Hubble Space Telescope Observations of the Interstellar Interloper 3I/ATLAS

The Astrophysical Journal Letters
We present high-angular-resolution observations of the third known interstellar interloper, 3I/ATLAS, from the Hubble Space Telescope. The object is clearly active at 3.8 au preperihelion, showing dust emitted from the hot, Sun-facing side of the nucleus
David Jewitt, Man-To Hui, Max Mutchler, Yoonyoung Kim, Jessica Agarwal   +4 more
doaj   +1 more source

Comet geology with Deep Impact remote sensing

, 2005
. The Deep Impact mission will provide the highest resolution images yet of a comet nucleus. Our knowledge of the makeup and structure of cometary nuclei, and the processes shaping their surfaces, is extremely limited, thus use of the Deep Impact data to
Peter C. Thomas, Michael F. A’hearn, Lucy Mcfadden, Jessica M. Sunshine, Joseph Veverka, Michael J. S. Belton   +5 more
core   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source