Results 31 to 40 of about 2,128 (236)

A JWST Study of the Remarkable Oort Cloud Comet C/2017 K2 (PanSTARRS)

The Planetary Science Journal
Comets, during their journeys into the inner solar system, deliver volatile gases, organics, and particulates into their comae that provide crucial information for assessing the physicochemical conditions in the outer disk from which they formed. Here we
Charles E. Woodward, Dominique Bockélee-Morvan, David E. Harker, Michael S. P. Kelley, Nathan X. Roth, Diane H. Wooden, Stefanie N. Milam   +6 more
doaj   +1 more source

Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors

Advanced Science, EarlyView.
Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu, WeiYi Cheng, Menghang Yang, Li He, WeiYe Ren, JingQuan Chen, LiTing He, Dandan Bao, Zhihong Zhu, Lixin Wang, Qinghua Yao, Ji‐Gang Piao   +11 more
wiley   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Unraveling the Water Sources in Comet 103P/Hartley 2 from Deep Impact Flyby Observations

The Planetary Science Journal
The Deep Impact eXtended Mission flyby of comet 103P/Hartley 2 offered a rare opportunity to study a hyperactive comet with high-cadence and high-resolution observations from a fixed vantage point.
L. M. Feaga, J. M. Sunshine
doaj   +1 more source

Origin and Evolution of Long-period Comets [PDF]

The Astronomical Journal, 2019
Abstract We develop an evolutionary model of the long-period comet (LPC) population, starting from their birthplace in a massive trans-Neptunian disk that was dispersed by migrating giant planets. Most comets that remain bound to the solar system are stored in the Oort cloud.
David Vokrouhlický, David Nesvorný, Luke Dones   +2 more
openaire   +2 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

COMETARY VOLATILES AND THE ORIGIN OF COMETS [PDF]

The Astrophysical Journal, 2012
We describe recent results on the CO/CO2/H2O composition of comets together with a survey of older literature (primarily for CO/H2O) and compare these with models of the protoplanetary disk. Even with the currently small sample, there is a wide dispersion in abundance ratios and little if any systematic difference between Jupiter-family comets (JFCs ...
A'Hearn, Michael F., Feaga, Lori M., Keller, H. Uwe, Kawakita, Hideyo, Hampton, Donald L., Kissel, Jochen, Klaasen, Kenneth P., Mcfadden, Lucy A., Meech, Karen J., Schultz, Peter H., Sunshine, Jessica M., Thomas, Peter C., Veverka, Joseph, Yeomans, Donald K., Besse, Sebastien, Bodewits, Dennis, Farnham, Tony L., Groussin, Olivier, Kelley, Michael S., Lisse, Carey M., Merlin, Frederic, Protopapa, Silvia, Wellnitz, Dennis D.   +22 more
openaire   +3 more sources

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Preperihelion CN Production Rate of Interstellar Comet 3I/ATLAS

The Astrophysical Journal Letters
We present spectroscopic observations of the third interstellar comet 3I/ATLAS obtained with the DOLORES instrument on the 3.58 m Telescopio Nazionale Galileo on 2025 August 16 ( r _h  = 2.98 au).
M. Lazzarin, A. C. Mura, F. La Forgia, G. Cremonese, P. Cambianica, G. Munaretto, A. Farina, E. Mazzotta Epifani, S. Ieva, E. Dotto   +9 more
doaj   +1 more source

Romanticism’s Longue Durée: the Woodstock Festival and History’s Journey Back to the Garden

Sillages Critiques
The Woodstock Festival of August 1969 was an inherently Romantic event, the apotheosis of spectacular countercultural aesthetics in the form of music, audience, dress, undress, discourses of freedom and rebellion, communal coexistence, social cooperation,
Eric Rosenberg
doaj   +1 more source