Results 41 to 50 of about 2,214 (245)

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Alternative Policy Designs to Help Farmers Select Profitable Conservation Practices

Agribusiness, EarlyView.
ABSTRACT Voluntary private carbon initiatives (VPCIs) promote the implementation of agricultural conservation practices that mitigate emissions of greenhouse gases (GHGs) via financial incentives to participating farmers. Simultaneously, an array of public policies supports the adoption of conservation practices through technical and financial ...
Oranuch Wongpiyabovorn, Alejandro Plastina   +1 more
wiley   +1 more source

A JWST Study of the Remarkable Oort Cloud Comet C/2017 K2 (PanSTARRS)

The Planetary Science Journal
Comets, during their journeys into the inner solar system, deliver volatile gases, organics, and particulates into their comae that provide crucial information for assessing the physicochemical conditions in the outer disk from which they formed. Here we
Charles E. Woodward, Dominique Bockélee-Morvan, David E. Harker, Michael S. P. Kelley, Nathan X. Roth, Diane H. Wooden, Stefanie N. Milam   +6 more
doaj   +1 more source

Dielectric Elastomer Actuators as Safe and Effective Tools for Mechanostimulation of Human Cells

Advanced Intelligent Systems, EarlyView.
Replicating physiological forces is crucial for realistic cell models. Dielectric elastomer actuators (DEAs) offer a soft alternative, though their high voltages raised toxicity concerns. We demonstrate that DEA stimulation causes no cell damage, cell death or cell‐cycle disruption, while activating mechanosensitive responses.
Simon Holzer, Chaimae Bahou, Noe Syfrig, Katia Monastyrskaya, Yoan Civet, Ali Hashemi Gheinani, Yves Perriard   +6 more
wiley   +1 more source

Integrating developmental and macroevolutionary approaches reveals a staminodial origin of all alternisepalous organs in Caryophyllaceae

American Journal of Botany, EarlyView.
Abstract Premise The identity of sterile floral organs in second‐whorl, alternisepalous positions within Caryophyllaceae remains contentious, having been described as staminodes, “petaloids,” or petals homologous with those of other Pentapetalae. Limited ingroup and outgroup sampling and floral developmental data and inadequate phylogenetic comparative
Riley J. Rees, Andrea D. Appleton, John J. Schenk   +2 more
wiley   +1 more source

Unraveling the Water Sources in Comet 103P/Hartley 2 from Deep Impact Flyby Observations

The Planetary Science Journal
The Deep Impact eXtended Mission flyby of comet 103P/Hartley 2 offered a rare opportunity to study a hyperactive comet with high-cadence and high-resolution observations from a fixed vantage point.
L. M. Feaga, J. M. Sunshine
doaj   +1 more source

Linear Viscoelastic Behavior of n‐Alkane Diluted Polyethylene Melts: Sorption, Desorption, and Oscillatory Rheometry

Journal of Applied Polymer Science, EarlyView.
This study systematically maps polyolefin dilution dynamics using a homologous series of n‐alkanes. Integrating gravimetric sorption, subsequent controlled desorption, and oscillatory rheometry establishes a precise framework to analyze reduction in viscosity at least for polymer diluent mixtures with polymer concentration > 35% and diluent ...
Ernst Georg Viehböck, Georg Gschwendner, Dario Pindrić, Gunnar Spiegel, Alexander Hammer, Christian Paulik, Gerald Berger‐Weber   +6 more
wiley   +1 more source

CO and N2 Produced from H2O, CO2, and NH3 Cometary Ice Analogs

The Astrophysical Journal
Hypervolatile species such as carbon monoxide (CO) and molecular nitrogen (N _2 ) have been detected in comets, and could be used to constrain comet formation temperature conditions if their presence is due to freeze-out and/or entrapment.
Alexandra McKinnon, Alexia Simon, Michelle R. Brann, Elettra L. Piacentino, Karin I. Öberg, Mahesh Rajappan   +5 more
doaj   +1 more source

Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs

The Anatomical Record, EarlyView.
Abstract Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.
Alexis Cornille, Kyla Beguesse, Ewan Wolff, Clemens Zinner, Patrick Asbach, François Clarac, Florian Witzmann   +6 more
wiley   +1 more source

Role of soft tissue and bone interactions in the developmental integration and modularity of the skull in neural crest‐specific gap junction alpha‐1 knockout mice

The Anatomical Record, EarlyView.
Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore, Madeline Tourigny, Diana Quinonez, Kevin Barr, Matthew W. Grol, Katherine E. Willmore   +5 more
wiley   +1 more source