Comet origins - Open Access .click

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Astronomical School’s Report, 2003
Three basic conceptions of origin of comets are under discussion. The first one belongs to Laplace who supposed that comets are becoming the members of the Solar system being captured by a giant planet, e.g. Jupiter. It is the hypothesis of capture. Oort supposed that there is a giant cloud of cometary nuclei at the heliocentric distance ∼105 AU.
openaire +2 more sources

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu +20 more
wiley +1 more source

NSF-DOE Vera C. Rubin Observatory Observations of Interstellar Comet 3I/ATLAS (C/2025 N1)

The Astrophysical Journal Letters
We report on the observation and measurement of astrometry, photometry, morphology, and activity of the interstellar object 3I/ATLAS, also designated C/2025 N1 (ATLAS) with the NSF-DOE Vera C. Rubin Observatory.
Colin Orion Chandler +305 more
doaj +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su +4 more
wiley +1 more source

Characterization of the Dust and Sodium Tails of Comet C/2020 F3 (NEOWISE) from Parker Solar Probe and Amateur Observations

The Planetary Science Journal
Comet C/2020 F3 (NEOWISE) reached perihelion on 2020 July 3 at 0.29 au and exhibited a highly structured dust tail. Using a simplified Finson–Probstein model, structures such as striae, observed in the tail in images obtained by the Parker Solar Probe ...
Qasim Afghan +4 more
doaj +1 more source

The Comet Interceptor mission to a dynamically new comet

, 2023
openL'elaborato mira ad affrontare il problema del tipo di manovre orbitali richieste per lo scopo della missione Comet Interceptor, ovvero il raggiungimento di un fly-by attorno a una cometa dinamicamente nuova proveniente dalla regione esterna al ...
SIMULA, SUSANNA
core

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen +7 more
wiley +1 more source

Down But Not Out: The Case of Long-period Comet C/2021 O3 (Panstarrs)

The Astronomical Journal
We combine ground- and space-based observations of long-period comet C/2021 O3 (Panstarrs; perihelion distance 0.287 au) in order to investigate its reported near-perihelion destruction.
David Jewitt +3 more
doaj +1 more source

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo +10 more
wiley +1 more source

The Ice Chemistry in Comets and Planet-forming Disks: Statistical Comparison of CH3OH, H2CO, and NH3 Abundance Ratios

The Astrophysical Journal Letters
Comets are frozen remnants of our solar system’s formation, and comparing their chemical composition to that of planet-forming systems can reveal crucial insights about our origins, potentially answering one of the most challenging questions in planetary
Manuela Lippi +7 more
doaj +1 more source

comets
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interstellar objects
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