Results 31 to 40 of about 2,214 (245)
Advanced Science, EarlyView.PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang +10 more
wiley +1 more source
Down But Not Out: The Case of Long-period Comet C/2021 O3 (Panstarrs)
The Astronomical JournalWe combine ground- and space-based observations of long-period comet C/2021 O3 (Panstarrs; perihelion distance 0.287 au) in order to investigate its reported near-perihelion destruction.
David Jewitt +3 more
doaj +1 more source
Advanced Science, EarlyView.Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu +9 more
wiley +1 more source
The Astrophysical Journal LettersComets are frozen remnants of our solar system’s formation, and comparing their chemical composition to that of planet-forming systems can reveal crucial insights about our origins, potentially answering one of the most challenging questions in planetary
Manuela Lippi +7 more
doaj +1 more source
Advanced Science, EarlyView.Conventional single‐gradient freeze‐casting typically produces unidirectional porous architectures with limited transverse connectivity. The Sequential Hybridization by Infiltration and Freeze‐casting Technique (SHIFT) addresses this constraint by integrating secondary aligned structures within a preformed primary scaffold.
Kiho Sung, Sungchul Shin
wiley +1 more source
Investigation of Split Comet 240P/NEAT
The Astronomical JournalWe present time-series observations of the split comet 240P/NEAT near perihelion, obtained using the Nordic Optical Telescope. The brighter component, 240P-A, has an estimated radius in the range 400–600 m, and loses dust at the peak rate 130 kg s ^−1 ...
David Jewitt, Jane Luu, Yoonyoung Kim
doaj +1 more source
REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma
Advanced Science, EarlyView.Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu +20 more
wiley +1 more source
The Interstellar Heritage of Comets
The Astronomical JournalComets have similar compositions to interstellar medium ices, suggesting at least some of their molecules may be inherited from an earlier stage of evolution.
Karen Willacy +7 more
doaj +1 more source
Advanced Science, EarlyView.ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su +4 more
wiley +1 more source
Gelato: A Mission Concept for Comet Surface Sample Return
The Planetary Science JournalUnderstanding the role of comets in solar system formation and evolution has continued to be a driving question in planetary science. It is believed that comets host a record of presolar history and early planet formation and likely delivered volatiles ...
Mallory J. Kinczyk +20 more
doaj +1 more source