Results 51 to 60 of about 531,799 (287)

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Investigation of Split Comet 240P/NEAT

The Astronomical Journal
We present time-series observations of the split comet 240P/NEAT near perihelion, obtained using the Nordic Optical Telescope. The brighter component, 240P-A, has an estimated radius in the range 400–600 m, and loses dust at the peak rate 130 kg s ^−1 ...
David Jewitt, Jane Luu, Yoonyoung Kim
doaj   +1 more source

Far‐UV emissions from the SL9 impacts with Jupiter [PDF]

, 1995
Observations with the International Ultraviolet Explorer (IUE) during the impacts of the fragments of comet D/Shoemaker-Levy 9 with Jupiter show far-UV emissions from the impact sites within a similar to 10 min time scale.
Liu, X, Rego, D, Fireman, G, Ajello, JM, Combi, M. R., Harris, W. M., Feldman, P. D., ben Jaffel, L., Liu, X., Strobel, DF, Jessup, K. L., Feldman, PD, Talavera, A., Livengood, T. A., Gladstone, GR, Budzien, SA, McGrath, MA, Clarke, J. T., ben Jaffel, L, Talavera, A, Prangé, R., Strobel, D. F., Ajello, J. M., Fireman, G., Vincent, M. B., Vincent, MB, Jessup, KL, Emerich, C., Miller, S., Hall, D. T., Combi, MR, Gladstone, G. R., McGrath, M. A., Woodney, L, Emerich, C, Rego, D., Budzien, S. A., Harris, WM, Miller, S, Clarke, JT, Ballester, GE, Livengood, TA, Ballester, G. E., Prangé, R, Woodney, L., Hall, DT   +45 more
core   +1 more source

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

Advanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok, Laura Činč Ćurić, Jernej Vajda, Silvia Schauer, Martin Wagner, Rudolf Stauber, Carolin Lackner, Karl Kashofer, Markus Plass, Giovanny Rodriguez Blanco, Ian R. Wanless, Uroš Maver, Katrin Panzitt, Boštjan Vihar   +13 more
wiley   +1 more source

The Interstellar Heritage of Comets

The Astronomical Journal
Comets have similar compositions to interstellar medium ices, suggesting at least some of their molecules may be inherited from an earlier stage of evolution.
Karen Willacy, Liton Majumdar, Boncho Bonev, Erika Gibb, Neil Dello Russo, Michael DiSanti, Ronald J. Vervack Jr., Nathan X. Roth   +7 more
doaj   +1 more source

PCLS (Precision Cut Lung Slices) as a putative model for genotoxicity testing by application of the comet assay

, 2022
S.2Actually, precision cut lung slices are under extensive investigation to serve as a model for acute inhalation toxicology. Slices can be employed as an ex-vivo/in-vitro model as alternative method in the context of REACH and the 3Rs. Moreover, this in
Sewald, K., Ritter, D., Knebel, J., Switalla, S.   +3 more
core   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Gelato: A Mission Concept for Comet Surface Sample Return

The Planetary Science Journal
Understanding the role of comets in solar system formation and evolution has continued to be a driving question in planetary science. It is believed that comets host a record of presolar history and early planet formation and likely delivered volatiles ...
Mallory J. Kinczyk, Gabriel E. Buffo, L. Miché Aaron-Hennig, Spencer Boone, Eric Frizzell, Abigail Flom, Chinmayee Govinda Raj, Camilla Harris, Ali Hyder, Benjamin Idini, Vidu Jayanetti, Spiridon Kasapis, Brennan McCann, Emily Millman, Alvin Ngo, Mary Ringwood, Laura E. Rodriguez, Amanda Rudolph, Karl Mitchell, Alfred Nash, William Smythe   +20 more
doaj   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

Synthetic Shewanella‐Bacillus Microbial Consortia for Enhanced Metal Oxide Leaching From Spent Lithium‐Ion Batteries Using Brewing Wastewater as Leaching Agent

Advanced Science, EarlyView.
A recycling approach of spent lithium‐ion batteries is developed using brewing wastewater as the leaching agent and an engineering microbial consortium as the biocatalyst. Shewanella oneidensis reduces spent LiNixCoyMn1‐x‐yO2 cathodes via extracellular electron transfer, while Bacillus subtilis removes residual ethanol to eliminate inhibition.
Baocai Zhang, Chunxiao Qiao, Huichun Liu, Yiyun Wang, Yan Liu, Huan Yu, Junqi Zhang, Chao Li, Deguang Wu, Qulai Tang, Zhiwen Wang, Danni Zhang, Dake Xu, Feng Li, Hao Song   +14 more
wiley   +1 more source