Results 51 to 60 of about 2,093,430 (321)
Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen +11 morewiley +1 more sourceNSF-DOE Vera C. Rubin Observatory Observations of Interstellar Comet 3I/ATLAS (C/2025 N1)
The Astrophysical Journal LettersWe report on the observation and measurement of astrometry, photometry, morphology, and activity of the interstellar object 3I/ATLAS, also designated C/2025 N1 (ATLAS) with the NSF-DOE Vera C. Rubin Observatory.Colin Orion Chandler, Pedro H. Bernardinelli, Mario Jurić, Devanshi Singh, Henry H. Hsieh, Ian Sullivan, R. Lynne Jones, Jacob A. Kurlander, Dmitrii Vavilov, Siegfried Eggl, Matthew Holman, Federica Spoto, Megan E. Schwamb, Lauren A. MacArthur, Rahil Makadia, Marco Micheli, Aren Heinze, Eric J. Christensen, Wilson Beebe, Aaron Roodman, Kian-Tat Lim, Tim Jenness, James Bosch, Brianna M. Smart, Eric Bellm, Sean MacBride, Meredith L. Rawls, Sarah Greenstreet, Colin Slater, Željko Ivezić, Robert D. Blum, Andrew Connolly, Gregory Daues, Michelle Gower, J. Bryce Kalmbach, Michele T. Bannister, Luke Dones, Rosemary C. Dorsey, Davide Farnocchia, Wesley C. Fraser, John C. Forbes, Cesar Fuentes, Carrie E. Holt, Laura Inno, Geraint H. Jones, Matthew M. Knight, Chris J. Lintott, Tim Lister, Robert Lupton, Mark Jesus M. Magbanua, Renu Malhotra, Beatrice E. A. Mueller, Joseph Murtagh, Nitya Pandey, William T. Reach, Nalin H. Samarasinha, Darryl Z. Seligman, Colin Snodgrass, Michael Solontoi, Gyula M. Szabó, Peter Vereš, Ellie White, Maria Womack, Leslie A. Young, Russ Allbery, Shreya Anand, Roberto Armellin, Éric Aubourg, Chrysa Avdellidou, Farrukh Azfar, James Bauer, Keith Bechtol, Valerie Becker, Matthew Belyakov, Susan D. Benecchi, Ivano Bertini, Dennis Bodewits, Patricia Boeshaar, Bryce T. Bolin, Maitrayee Bose, Alexandre Boucaud, Rodrigo C. Boufleur, Dominique Boutigny, Andrew Bradshaw, Felipe Braga-Ribas, Johan Bregeon, Laura E. Buchanan, Daniel Calabrese, J. I. B. Camargo, Neven Caplar, Jeffrey L. Carlin, Benoit Carry, Juan Pablo Carvajal, Ross Ceballo, Hsin-Fang Chiang, Yumi Choi, Céline Combet, Luiz da Costa, Preeti Cowan, John Franklin Crenshaw, Steve Croft, Matija Ćuk, Philip N. Daly, Filippo D’Ammando, Felipe Daruich, Guillaume Daubard, James R. A. Davenport, Tansu Daylan, Jennifer Delgado, Hadrien A. R. Devillepoix, Peter E. Doherty, Abbie Donaldson, Holger Drass, Stephanie J. H. Deppe, Gregory P. Dubois-Felsmann, Peter S. Ferguson, Frossie Economou, Marielle R. Eduardo, Ioana Sotuela Elorriaga, Anthony Englert, Edward Karavakis, Kevin Fanning, Maxwell K. Frissell, Grigori Fedorets, Maryann Benny Fernandes, Agnès Ferté, Merlin Fisher-Levine, Mark L Freytag, Marco Fulle, Poshak Gandhi, John Gates, David W. Gerdes, Alex R. Gibbs, A. Fraser Gillan, Massimiliano Giordano Orsini, T. Glanzman, Iain Goodenow, Altair Ramos Gomes-Júnior, Miranda R. Gorsuch, Mikael Granvik, Wen Guan, Leanne P. Guy, Mark Hammergren, Andrew Hanushevsky, Fabio Hernandez, Ǎdis Herrold, Daniel Hestroffer, Joshua Hoblitt, Guillem Megias Homar, Matthew J. Hopkins, Simone Ieva, Patrick Ingraham, David H. Irving, Buell T. Jannuzi, M. James Jee, David Jimenez, Claire Juramy, Steven M. Kahn, Yijung Kang, Arun Kannawadi, JJ Kavelaars, Michael S. P. Kelley, Kshitija Kelkar, Lee S. Kelvin, Ivan Kotov, Alec Koumjian, Gábor Kovács, K. Simon Krughoff, Agnieszka Kryszczyńska, Petr Kubánek, Craig Lage, Travis J. Lange, Pierre-François Léget, Laurent Le Guillou, Benjamin Levine, W. Garrett Levine, Zhuofu (Chester) Li, Shuang Liang, Javier Licandro, Hsing Wen Lin, Carey Lisse, Nate B. Lust, Ryan R. Lyttle, Ashish A. Mahabal, Max Mahlke, Gabriele Mainetti, Rachel Mandelbaum, Steven J. Margheim, Giuliano Margoti, Phil Marshall, Andrés A. Plazas Malagón, Dušan Marčeta, Mario D. Melita, Felipe Menanteau, Joshua Meyers, Dave Mills, Marc Moniez, C.A.L. Morales Marín, Naomi Morato, Surhud More, Christopher B. Morrison, Kris Mortensen, Youssef Moulane, Karlo Mrakovčić, Fritz Mueller, Marco A. Muñoz-Gutiérrez, Homer Neal, F. M. Newcomer, Erfan Nourbakhsh, Paul O’Connor, Drew Oldag, William J. Oldroyd, William O’Mullane, Cyrielle Opitom, Dagmara Oszkiewicz, Gary L. Page, Jack Patterson, Maria T Patterson, Matthew J. Payne, Eske M. Pedersen, Julien Peloton, Chrystian Luciano Pereira, John R. Peterson, Stephen R. Pietrowicz, Edyta Podlewska-Gaca, Rebekah Polen, Daniel Polin, Hannah Mary Margaret Pollek, Yongqiang Qiu, Bruno Quint, Markus Rabus, Darin Ragozzine, Jayadev Rajagopal, Arianna Ranabhat, Kevin Reil, Tiago Ribeiro, Malena Rice, Stephen T. Ridgway, Steven M. Ritz, Andrew S. Rivkin, James E. Robinson, Agata Rożek, Eli Rykoff, Luis E. Salazar Manzano, Andrei Salnikov, Bruno O. Sánchez, David Sanmartim, Gal Sarid, Charles A. Schambeau, Rafe H. Schindler, Samuel J. Schmidt, German Schumacher, Theo Schutt, Daniel Scolnic, Robert Seaman, Jacques Sebag, Nima Sedaghat, Jacqueline Seron, Richard A. Shaw, Alysha Shugart, Jonathan Sick, Jaladh Singhal, Amir Siraj, Michael C. Sitarz, Adam Snyder, Shahram Sobhani, Christine Soldahl, Dallin Spencer, Brian Stalder, Steven Stetzler, Alan Strauss, Christopher W. Stubbs, Krzysztof L. Suberlak, John D. Swinbank, László Szigeti, Dan S. Taranu, Michael Tauraso, John Gregg Thayer, Sandrine Thomas, Adam Thornton, Luca Tonietti, Laura Toribio San Cipriano, David E. Trilling, Chadwick A. Trujillo, Te-Wei Tsai, Douglas L. Tucker, Max Turri, Tony Tyson, Elana K. Urbach, Wouter van Reeven, Antonia Sierra Villarreal, Stelios Voutsinas, Christopher W. Walter, Yuankun (David) Wang, Charlotte Ward, Michael Warner, Maxine West, Emerson Whittaker, Ian Wong, W. M. Wood-Vasey, Bin Yang, Quanzhi Ye, Peter Yoachim, R. Zanmar Sanchez, Jinshuo Zhang, Conghao Zhou +305 moredoaj +1 more sourceβ‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair
Advanced Science, EarlyView.This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue +10 morewiley +1 more sourceLight‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction
Advanced Science, EarlyView.Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi +7 morewiley +1 more sourcePhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries
Advanced Science, EarlyView.PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi +10 morewiley +1 more source
