Results 51 to 60 of about 2,103,717 (319)

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

The Interstellar Heritage of Comets

The Astronomical Journal
Comets have similar compositions to interstellar medium ices, suggesting at least some of their molecules may be inherited from an earlier stage of evolution.
Karen Willacy, Liton Majumdar, Boncho Bonev, Erika Gibb, Neil Dello Russo, Michael DiSanti, Ronald J. Vervack Jr., Nathan X. Roth   +7 more
doaj   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

The cometary composition of a protoplanetary disk as revealed by complex cyanides

, 2015
Observations of comets and asteroids show that the Solar Nebula that spawned our planetary system was rich in water and organic molecules. Bombardment brought these organics to the young Earth's surface, seeding its early chemistry.
A Dutrey, A Dutrey, C Brinch, C Favre, C Qi, C Qi, C Qi, C Walsh, C Walsh, C Walsh, C Walsh, Chunhua Qi, D Lynden-Bell, D Semenov, David J. Wilner, DM Graninger, DP O’Brien, E Bergin, E Dartois, E Herbst, EC Fayolle, EF van Dishoeck, EF van Dishoeck, EI Chiang, FJ Ciesla, GM Muñoz Caro, H Nomura, JS Carr, K Furuya, K Tsiganis, KA Rosenfeld, Karin I. Öberg, Kenji Furuya, KI Öberg, KI Öberg, KI Öberg, KJ Walsh, KM Pontoppidan, L Hartmann, LI Cleeves, LI Cleeves, M Dubernet, M Simon, M Takami, M Wernli, MJ Mumma, MP Collings, MR Hogerheijde, N Goldman, N Sakai, P D'Alessio, P Gratier, P Hartogh, RT Garrod, Ryan Loomis, S Guilloteau, S Pizzarello, Sean M. Andrews, T Yamamoto, V Piétu, V Wakelam, Viviana V. Guzmán, Y Aikawa, Y Aikawa, Yuri Aikawa   +64 more
core   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

A JWST Study of the Remarkable Oort Cloud Comet C/2017 K2 (PanSTARRS)

The Planetary Science Journal
Comets, during their journeys into the inner solar system, deliver volatile gases, organics, and particulates into their comae that provide crucial information for assessing the physicochemical conditions in the outer disk from which they formed. Here we
Charles E. Woodward, Dominique Bockélee-Morvan, David E. Harker, Michael S. P. Kelley, Nathan X. Roth, Diane H. Wooden, Stefanie N. Milam   +6 more
doaj   +1 more source

Carbon monoxide in the distantly active Centaur (60558) 174P/Echeclus at 6 AU

, 2017
(60558) 174P/Echeclus is an unusual object that belongs to a class of minor planets called Centaurs, which may be intermediate between Kuiper Belt Objects and Jupiter Family comets.
Sarid, Gal, Wierzchos, Kacper, Womack, Maria   +2 more
core   +1 more source

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

Origin and Evolution of Long-period Comets [PDF]

The Astronomical Journal, 2019
Abstract We develop an evolutionary model of the long-period comet (LPC) population, starting from their birthplace in a massive trans-Neptunian disk that was dispersed by migrating giant planets. Most comets that remain bound to the solar system are stored in the Oort cloud.
David Vokrouhlický, David Nesvorný, Luke Dones   +2 more
openaire   +2 more sources

Alternative Policy Designs to Help Farmers Select Profitable Conservation Practices

Agribusiness, EarlyView.
ABSTRACT Voluntary private carbon initiatives (VPCIs) promote the implementation of agricultural conservation practices that mitigate emissions of greenhouse gases (GHGs) via financial incentives to participating farmers. Simultaneously, an array of public policies supports the adoption of conservation practices through technical and financial ...
Oranuch Wongpiyabovorn, Alejandro Plastina   +1 more
wiley   +1 more source