Results 121 to 130 of about 535,368 (303)

cGAS–STING Pathway Activation Enhances Antitumor Effect of Talaporfin Photodynamic Therapy Through ROS Production

Cancer Science, EarlyView.
This study investigates the role of STING in photodynamic therapy (PDT) using talaporfin sodium. STING knockout reduced ROS generation and therapeutic efficacy, while combining a STING agonist with PDT enhanced antitumor effects. These findings suggest that STING regulates ROS homeostasis and can potentiate PDT outcomes.
Makiko Sasaki, Mamoru Tanaka, Yasunari Sasaki, Yuki Kojima, Taketo Suzuki, Hirotada Nishie, Shigeki Fukusada, Naomi Sugimura, Keiji Ozeki, Takaya Shimura, Eiji Kubota, Hiromi Kataoka   +11 more
wiley   +1 more source

Spectroscopic observations of comet Kohoutek (1973f), 2 [PDF]

Spectroscopic observations of comet Kohoutek at the Asiago Astrophysical Observatory are described. Spectra cover six nights before perihelion and five nights after perihelion.
Benvenuti, P.
core   +1 more source

The Sunward Tail of Comet Arend-Roland [PDF]

, 1957
Fred L. Whipple
openalex   +1 more source

Elucidating the Role and Mechanism of Alpha‐Enolase in Senescent Amelioration via Metabolic Reprogramming

Cell Proliferation, EarlyView.
KB2764 interacted with alpha‐enolase (ENO1) and pyruvate kinase M (PKM), ultimately leading to PKM phosphorylation of ENO1. KB2764 consequently increased mitochondrial ATP production and decreased glycolysis dependence. Furthermore, the action of KB2764 extends its application to extend the lifespan of Caenorhabditis elegans.
Yun Haeng Lee, Hyunwoong Lim, Gyungmin Kim, Geonhee Jang, Myeong Uk Kuk, Ji Ho Park, Jee hee Yoon, Yoo Jin Lee, Duyeol Kim, Byeonghyeon So, Minseon Kim, Hyung Wook Kwon, Youngjoo Byun, Joon Tae Park   +13 more
wiley   +1 more source

The study of comets, part 2 [PDF]

Flyby missions and systematic observations of comets are projected for studying comet nuclei and cometary dust tail ...
Ahearn, M., Donn, B., Harrington, R., Jackson, W. M., Mumma, M.   +4 more
core   +1 more source

Cytotoxic Effect of Nefazodone on HepG2 Cell Line and the Reliability of Comet Assay to Determine Genotoxicity.

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2019
Nefazodone is atypical antidepressant which was manufactured by Bristol-Myers Squibb in 1994 to avoid the adverse effects associated with other antidepressants, including nausea, sedation, insomnia, cardiovascular toxi-city, weight gain and dysfunction.
Mustafa Tariq Sakin, Yassir Mustafa Kamal   +1 more
doaj   +1 more source

RBM39 Promotes Base Excision Repair to Facilitate the Progression of HCC by Stabilising OGG1 mRNA

Cell Proliferation, EarlyView.
Targeting RBM39 attenuates BER via destabilising OGG1 mRNA and potentiates KBrO3‐induced oxidative stress in HCC. Our study represents a valuable treatment strategy combining indisulam and an oxidative stress inducer in HCC. ABSTRACT Targeting base excision repair (BER) has been an attractive strategy in cancer therapeutics.
Hongda An, Anliang Xia, Siyuan Liu, Dongjun Luo, Longpo Geng, Binghua Li, Beicheng Sun, Zhu Xu   +7 more
wiley   +1 more source

Analysis of the ICE combiner for multiple antenna arraying [PDF]

The passage of the International Cometary Explorer (ICE) through the tail of comet Giacobini-Zinner took place on September 11, 1985, at approximately 11:04 GMT.
Foster, C., Marina, M.
core   +1 more source

Genotoxic effects in blood cells of sturger (Acipenseridae) grown in conditions of cage farming of the Volga delta, Russia

Юг России: экология, развитие
The purpose of this work was to assess the degree of genotoxic influence of the habitat on individuals of Russian sturgeon and sterlet raised in cage farming conditions in the Volga delta, using micronucleus and DNA comet tests.The blood of the ...
A. V. Konkova, D. R. Faizulina, Yu. M. Shirina, I. A. Bogatov   +3 more
doaj   +1 more source

The Tail of Halley's Comet on May 18–19 [PDF]

, 1910
HOWARD PAYN
openalex   +1 more source