Results 51 to 60 of about 106,793 (279)

Actin filament and branch geometry in comet tails under TIRF microscopy.

open access: yes, 2012
Conditions: A–B, 8.5 µM (8% labeled) actin, 9 µM profilin, 100 nM Arp2/3, CP as indicated; C–E, 2 µM (10% labeled) actin, 3 µM profilin, 20 nM Arp2/3, 40 nM CP; F–H, 8.5 µM (8% labeled) actin, 9 µM profilin, 100 nM Arp2/3, CP as indicated; nanofibers ...
Xiaohua Hu (39389)   +1 more
core   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

open access: yesAdvanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao   +25 more
wiley   +1 more source

Solar Wind Interactions with Comet C/2021 A1 Using STEREO HI and a Data-assimilative Solar Wind Model

open access: yesThe Astrophysical Journal
Cometary tails display dynamic behavior attributed to interactions with solar wind structures. Consequently, comet-tail observations can serve as in situ solar wind monitors.
Sarah R. Watson   +3 more
doaj   +1 more source

Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD

open access: yesAdvanced Science, EarlyView.
This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu   +20 more
wiley   +1 more source

RAD18 confers radioresistance of esophagus squamous cell carcinoma through regulating p‐DNA‐PKcs

open access: yesCancer Medicine, 2022
Background Radiotherapy has recently become more common for the treatment of esophageal squamous cell carcinoma (ESCC). Radioresistance, on the other hand, continues to be a major issue because it interferes with the effectiveness of ESCC radiation.
Xiaoqing Li   +8 more
doaj   +1 more source

Latitudinal properties of the solar wind from studies of ionic comet tails [PDF]

open access: yes, 1976
A statistical analysis is presented of the orientations of ionic comet tails in the solar wind. The analysis indicates that the radial solar wind speed is not necessarily higher near the solar poles than near the equator. The results refer to a long-term,
Brandt, J. C.
core  

MPP8 Facilitates DNA DSB Repair via NHEJ to Promote Chemoresistance of TNBC Independent of Methyl‐H3K9 Binding

open access: yesAdvanced Science, EarlyView.
Chemoresistance is often linked to elevated DNA repair. MPP8 is found to promote breast cancer chemoresistance as a novel NHEJ accessory factor independent of its epigenetic functions. Through multiple protein interactions, MPP8 facilitates association of DNAPK and ligase complexes to promote DNA repair progression.
Rupa Kumari, Jia Fang
wiley   +1 more source

NSF-DOE Vera C. Rubin Observatory Observations of Interstellar Comet 3I/ATLAS (C/2025 N1)

open access: yesThe Astrophysical Journal Letters
We report on the observation and measurement of astrometry, photometry, morphology, and activity of the interstellar object 3I/ATLAS, also designated C/2025 N1 (ATLAS) with the NSF-DOE Vera C. Rubin Observatory.
Colin Orion Chandler   +305 more
doaj   +1 more source

On the Formation of the Tails of Comets [PDF]

open access: yesScientific American, 1881
n ...
openaire   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

open access: yesAdvanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao   +10 more
wiley   +1 more source

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