Results 51 to 60 of about 106,793 (279)
Actin filament and branch geometry in comet tails under TIRF microscopy.
, 2012 Conditions: A–B, 8.5 µM (8% labeled) actin, 9 µM profilin, 100 nM Arp2/3, CP as indicated; C–E, 2 µM (10% labeled) actin, 3 µM profilin, 20 nM Arp2/3, 40 nM CP; F–H, 8.5 µM (8% labeled) actin, 9 µM profilin, 100 nM Arp2/3, CP as indicated; nanofibers ...Xiaohua Hu (39389), Jeffrey R. Kuhn (183525) +1 morecore +1 more sourceStimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen
Advanced Science, EarlyView.Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel +25 morewiley +1 more sourceAlkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD
Advanced Science, EarlyView.This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.Shiyun Liu, Yufei Sun, Xinlei Wu, Haixia Chen, Shaocong Mo, Zichong Li, Yiwei Gong, Xiaoqian Shan, Yuanqi Li, Yaru Guan, Junqi Zhu, Han Yan, Min Du, Feng Wei, Peixin Ou, Ziyi Wang, Chenting Zhang, Lei Xu, Wenju Lu, Jian Wang, Kai Yang +20 morewiley +1 more sourceRAD18 confers radioresistance of esophagus squamous cell carcinoma through regulating p‐DNA‐PKcs
Cancer Medicine, 2022 Background Radiotherapy has recently become more common for the treatment of esophageal squamous cell carcinoma (ESCC). Radioresistance, on the other hand, continues to be a major issue because it interferes with the effectiveness of ESCC radiation.Xiaoqing Li, Shitao Zou, Liangsu Zhou, Aidi Gao, Jing Xu, Chao He, Jundong Zhou, Shuhua Wu, Yihong Chen +8 moredoaj +1 more sourceNSF-DOE Vera C. Rubin Observatory Observations of Interstellar Comet 3I/ATLAS (C/2025 N1)
The Astrophysical Journal LettersWe report on the observation and measurement of astrometry, photometry, morphology, and activity of the interstellar object 3I/ATLAS, also designated C/2025 N1 (ATLAS) with the NSF-DOE Vera C. Rubin Observatory.Colin Orion Chandler, Pedro H. Bernardinelli, Mario Jurić, Devanshi Singh, Henry H. Hsieh, Ian Sullivan, R. Lynne Jones, Jacob A. Kurlander, Dmitrii Vavilov, Siegfried Eggl, Matthew Holman, Federica Spoto, Megan E. Schwamb, Lauren A. MacArthur, Rahil Makadia, Marco Micheli, Aren Heinze, Eric J. Christensen, Wilson Beebe, Aaron Roodman, Kian-Tat Lim, Tim Jenness, James Bosch, Brianna M. Smart, Eric Bellm, Sean MacBride, Meredith L. Rawls, Sarah Greenstreet, Colin Slater, Željko Ivezić, Robert D. Blum, Andrew Connolly, Gregory Daues, Michelle Gower, J. Bryce Kalmbach, Michele T. Bannister, Luke Dones, Rosemary C. Dorsey, Davide Farnocchia, Wesley C. Fraser, John C. Forbes, Cesar Fuentes, Carrie E. Holt, Laura Inno, Geraint H. Jones, Matthew M. Knight, Chris J. Lintott, Tim Lister, Robert Lupton, Mark Jesus M. Magbanua, Renu Malhotra, Beatrice E. A. Mueller, Joseph Murtagh, Nitya Pandey, William T. Reach, Nalin H. Samarasinha, Darryl Z. Seligman, Colin Snodgrass, Michael Solontoi, Gyula M. Szabó, Peter Vereš, Ellie White, Maria Womack, Leslie A. Young, Russ Allbery, Shreya Anand, Roberto Armellin, Éric Aubourg, Chrysa Avdellidou, Farrukh Azfar, James Bauer, Keith Bechtol, Valerie Becker, Matthew Belyakov, Susan D. Benecchi, Ivano Bertini, Dennis Bodewits, Patricia Boeshaar, Bryce T. Bolin, Maitrayee Bose, Alexandre Boucaud, Rodrigo C. Boufleur, Dominique Boutigny, Andrew Bradshaw, Felipe Braga-Ribas, Johan Bregeon, Laura E. Buchanan, Daniel Calabrese, J. I. B. Camargo, Neven Caplar, Jeffrey L. Carlin, Benoit Carry, Juan Pablo Carvajal, Ross Ceballo, Hsin-Fang Chiang, Yumi Choi, Céline Combet, Luiz da Costa, Preeti Cowan, John Franklin Crenshaw, Steve Croft, Matija Ćuk, Philip N. Daly, Filippo D’Ammando, Felipe Daruich, Guillaume Daubard, James R. A. Davenport, Tansu Daylan, Jennifer Delgado, Hadrien A. R. Devillepoix, Peter E. Doherty, Abbie Donaldson, Holger Drass, Stephanie J. H. Deppe, Gregory P. Dubois-Felsmann, Peter S. Ferguson, Frossie Economou, Marielle R. Eduardo, Ioana Sotuela Elorriaga, Anthony Englert, Edward Karavakis, Kevin Fanning, Maxwell K. Frissell, Grigori Fedorets, Maryann Benny Fernandes, Agnès Ferté, Merlin Fisher-Levine, Mark L Freytag, Marco Fulle, Poshak Gandhi, John Gates, David W. Gerdes, Alex R. Gibbs, A. Fraser Gillan, Massimiliano Giordano Orsini, T. Glanzman, Iain Goodenow, Altair Ramos Gomes-Júnior, Miranda R. Gorsuch, Mikael Granvik, Wen Guan, Leanne P. Guy, Mark Hammergren, Andrew Hanushevsky, Fabio Hernandez, Ǎdis Herrold, Daniel Hestroffer, Joshua Hoblitt, Guillem Megias Homar, Matthew J. Hopkins, Simone Ieva, Patrick Ingraham, David H. Irving, Buell T. Jannuzi, M. James Jee, David Jimenez, Claire Juramy, Steven M. Kahn, Yijung Kang, Arun Kannawadi, JJ Kavelaars, Michael S. P. Kelley, Kshitija Kelkar, Lee S. Kelvin, Ivan Kotov, Alec Koumjian, Gábor Kovács, K. Simon Krughoff, Agnieszka Kryszczyńska, Petr Kubánek, Craig Lage, Travis J. Lange, Pierre-François Léget, Laurent Le Guillou, Benjamin Levine, W. Garrett Levine, Zhuofu (Chester) Li, Shuang Liang, Javier Licandro, Hsing Wen Lin, Carey Lisse, Nate B. Lust, Ryan R. Lyttle, Ashish A. Mahabal, Max Mahlke, Gabriele Mainetti, Rachel Mandelbaum, Steven J. Margheim, Giuliano Margoti, Phil Marshall, Andrés A. Plazas Malagón, Dušan Marčeta, Mario D. Melita, Felipe Menanteau, Joshua Meyers, Dave Mills, Marc Moniez, C.A.L. Morales Marín, Naomi Morato, Surhud More, Christopher B. Morrison, Kris Mortensen, Youssef Moulane, Karlo Mrakovčić, Fritz Mueller, Marco A. Muñoz-Gutiérrez, Homer Neal, F. M. Newcomer, Erfan Nourbakhsh, Paul O’Connor, Drew Oldag, William J. Oldroyd, William O’Mullane, Cyrielle Opitom, Dagmara Oszkiewicz, Gary L. Page, Jack Patterson, Maria T Patterson, Matthew J. Payne, Eske M. Pedersen, Julien Peloton, Chrystian Luciano Pereira, John R. Peterson, Stephen R. Pietrowicz, Edyta Podlewska-Gaca, Rebekah Polen, Daniel Polin, Hannah Mary Margaret Pollek, Yongqiang Qiu, Bruno Quint, Markus Rabus, Darin Ragozzine, Jayadev Rajagopal, Arianna Ranabhat, Kevin Reil, Tiago Ribeiro, Malena Rice, Stephen T. Ridgway, Steven M. Ritz, Andrew S. Rivkin, James E. Robinson, Agata Rożek, Eli Rykoff, Luis E. Salazar Manzano, Andrei Salnikov, Bruno O. Sánchez, David Sanmartim, Gal Sarid, Charles A. Schambeau, Rafe H. Schindler, Samuel J. Schmidt, German Schumacher, Theo Schutt, Daniel Scolnic, Robert Seaman, Jacques Sebag, Nima Sedaghat, Jacqueline Seron, Richard A. Shaw, Alysha Shugart, Jonathan Sick, Jaladh Singhal, Amir Siraj, Michael C. Sitarz, Adam Snyder, Shahram Sobhani, Christine Soldahl, Dallin Spencer, Brian Stalder, Steven Stetzler, Alan Strauss, Christopher W. Stubbs, Krzysztof L. Suberlak, John D. Swinbank, László Szigeti, Dan S. Taranu, Michael Tauraso, John Gregg Thayer, Sandrine Thomas, Adam Thornton, Luca Tonietti, Laura Toribio San Cipriano, David E. Trilling, Chadwick A. Trujillo, Te-Wei Tsai, Douglas L. Tucker, Max Turri, Tony Tyson, Elana K. Urbach, Wouter van Reeven, Antonia Sierra Villarreal, Stelios Voutsinas, Christopher W. Walter, Yuankun (David) Wang, Charlotte Ward, Michael Warner, Maxine West, Emerson Whittaker, Ian Wong, W. M. Wood-Vasey, Bin Yang, Quanzhi Ye, Peter Yoachim, R. Zanmar Sanchez, Jinshuo Zhang, Conghao Zhou +305 moredoaj +1 more sourceLactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair
Advanced Science, EarlyView.A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang +10 morewiley +1 more source