Results 31 to 40 of about 101,128 (273)

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Characterization of the Dust and Sodium Tails of Comet C/2020 F3 (NEOWISE) from Parker Solar Probe and Amateur Observations

The Planetary Science Journal
Comet C/2020 F3 (NEOWISE) reached perihelion on 2020 July 3 at 0.29 au and exhibited a highly structured dust tail. Using a simplified Finson–Probstein model, structures such as striae, observed in the tail in images obtained by the Parker Solar Probe ...
Qasim Afghan, Geraint H. Jones, Karl Battams, Oliver Price, Andrew J. Coates   +4 more
doaj   +1 more source

MED1, a novel binding partner of BRCA1, regulates homologous recombination and R-loop processing

Scientific Reports, 2022
Homologous recombination (HR) is a major repair pathway of DNA double-strand breaks and is closely related to carcinogenesis. HR deficiency has been established as a therapeutic target.
Harunori Honjoh, Michihiro Tanikawa, Osamu Wada-Hiraike, Katsutoshi Oda, Hirofumi Inaba, Asako Kukita, Yoshiko Kawata, Misako Kusakabe, Saki Tsuchimochi, Ayumi Taguchi, Yuichiro Miyamoto, Kenbun Sone, Tetsushi Tsuruga, Mayuyo Mori-Uchino, Yoko Matsumoto, Yutaka Osuga   +15 more
doaj   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Recurrent Cometary Activity Discovered on Quasi-Hilda Jupiter Family Comet 362P/(457175) 2008 GO98

The Astrophysical Journal Letters
We report the discovery of recurrent activity on quasi-Hilda comet (QHC) 362P/(457175) 2008 GO _98 . The first activity epoch was discovered during the perihelion passage of 362P in 2016, so we were motivated to observe it for recurrent cometary activity
Kennedy A. Farrell, Colin Orion Chandler, Chadwick A. Trujillo, William J. Oldroyd, Jarod A. DeSpain, Mark Jesus Mendoza Magbanua, Maxwell K. Frissell, Phineas Stone   +7 more
doaj   +1 more source

Cytotoxicity and Genotoxicity Evaluation of Fluorapatite/bioactive Glass Nanocomposite Foams With Two Various Weight Ratios as Bone Tissue Scaffold: an in vitro study [PDF]

Iranian Journal of Materials Science and Engineering, 2022
The optimization of biomaterials biodegradation rate similar to tissue regeneration, is one of the main goals in the field of tissue engineering. However, the necessity to assess their possible toxicity is always considered.
Ebrahim Zabihi, Roghayeh Pourbagher, Seyedali Seyedmajidi   +2 more
doaj  

In vitro assembled baculovirus comet tails.

, 2014
Images of viruses and actin tails obtained in in vitro assays after negative staining and conventional transmission EM. (A) Budded baculovirus in the infected cell supernatant. (B) De-enveloped virus obtained after detergent treatment of the budded virus.
Julia Pfanzelter (508928), J. Victor Small (222108), Taro Ohkawa (508929), Christoph Winkler (80764), Yuichiro Maeda (809018), Jan Mueller (508927), Akihiro Narita (246290), Marie-France Carlier (203714), Maria Nemethova (222097), Matthew D. Welch (322445), Christophe Le Clainche (248278), Christian Schmeiser (508930), Guenter P. Resch (508931)   +12 more
core   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Statistical Analysis of Comet Disconnection Events Using STEREO HI and a Data-assimilative Solar Wind Model

The Astrophysical Journal
Comets tails can reveal information about the local solar wind conditions. They can exhibit various signatures of interactions with the solar wind including bending, developing kinks, and sometimes undergoing tail disconnections.
Sarah Watson, Chris Scott, Mathew Owens, Luke Barnard, Matthew Lang   +4 more
doaj   +1 more source

Assessment of Cellular Damage by Comet Assay After Photodynamic Therapy in vitro

Acta Medica, 2004
The aim of this study was analysis of DNA damage in the cell line of the human melanoma G361 after photodynamic therapy (PDT) by comet assay. Photodynamic therapy is based on cytotoxic action of sensitizers (10 µM ZnTPPS4 fixed into 1 mM cyclodextrin ...
Jaroslav Maceček, Hana Kolářová, Jitka Psotová, Robert Bajgar, Martin Huf, Pavla Nevřelová, Marek Tomečka, Jiří Mosinger   +7 more
doaj   +1 more source